EC number:4.4.1.2
Enzyme
Download| EC Tree |
| 4. Lyases |
| 4.4 Carbon-sulfur lyases |
| 4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date) |
| ID: | 4.4.1.2 |
|---|---|
| Description: | Homocysteine desulfhydrase. |
| Alternative Name: |
Homocysteine desulfurase. |
| Cath: | 3.40.640.10; 3.90.1150.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.4.1.2 |
| BRENDA Enzyme Link: | BRENDA 4.4.1.2 |
| KEGG Enzyme Link: | KEGG4.4.1.2 |
| BioCyc Enzyme Link: | BioCyc 4.4.1.2 |
| ExPASy Enzyme Link: | ExPASy4.4.1.2 |
| EC2PDB Enzyme Link: | EC2PDB 4.4.1.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.4.1.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.4.1.2 |
| IntEnz Enzyme Link: | IntEnz 4.4.1.2 |
| MEDLINE Enzyme Link: | MEDLINE 4.4.1.2 |
| RHEA:14501 | H2O + L-homocysteine = 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+) |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[NH2;+0:3])-[*:4]-[CH2;+0:5]-[SH;+0:6].[OH2;+0:7]>>[*:1]-[C;H0;+0:2](=[O;H0;+0:7])-[*:4]-[CH3;+0:5].[NH3;+0:3].[SH2;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification of bacterial L-methionine gamma-lyase. | Nakayama T, Esaki N, Sugie K, Beresov TT, Tanaka H, Soda K | 1984 May 1 | 6742420 |
| The role of amino acid residues in the active site of L-methionine γ-lyase from Pseudomonas putida. | Fukumoto M, Kudou D, Murano S, Shiba T, Sato D, Tamura T, Harada S, Inagaki K | 2012 | 22785484 |
| Conversion of methionine to cysteine in Bacillus subtilis and its regulation. | Hullo MF, Auger S, Soutourina O, Barzu O, Yvon M, Danchin A, Martin-Verstraete I | 2007 Jan | 17056751 |
| High production of methyl mercaptan by L-methionine-alpha-deamino-gamma-mercaptomethane lyase from Treponema denticola. | Fukamachi H, Nakano Y, Okano S, Shibata Y, Abiko Y, Yamashita Y | 2005 May 27 | 15845368 |
| Function of pyridoxal phosphate in desulfhydrase systems of Proteus morganii. | KALLIO RE | 1951 Sep | 14917685 |
| 3-Chloro-DL-alanine resistance by L-methionine-alpha-deamino-gamma-mercaptomethane-lyase activity. | Yoshimura M, Nakano Y, Fukamachi H, Koga T | 2002 Jul 17 | 12123816 |