EC number:4.4.1.20
Enzyme
Download| EC Tree |
| 4. Lyases |
| 4.4 Carbon-sulfur lyases |
| 4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date) |
| ID: | 4.4.1.20 |
|---|---|
| Description: | Leukotriene-C(4) synthase. |
| Alternative Name: |
LTC(4) synthetase. LTC(4) synthase. Leukotriene C(4) synthetase. Leukotriene A(4):glutathione S-leukotrienyltransferase. |
| Prosite: | PDOC00999; |
| PDB: |
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| Cath: | 1.20.120.550; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.4.1.20 |
| BRENDA Enzyme Link: | BRENDA 4.4.1.20 |
| KEGG Enzyme Link: | KEGG4.4.1.20 |
| BioCyc Enzyme Link: | BioCyc 4.4.1.20 |
| ExPASy Enzyme Link: | ExPASy4.4.1.20 |
| EC2PDB Enzyme Link: | EC2PDB 4.4.1.20 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.4.1.20 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.4.1.20 |
| IntEnz Enzyme Link: | IntEnz 4.4.1.20 |
| MEDLINE Enzyme Link: | MEDLINE 4.4.1.20 |
| RHEA:17617 | leukotriene C4 = glutathione + leukotriene A4 |
| RULE(radius=1) | [*:1]-[S;H0;+0:2]-[CH;+0:3](-[*:4])-[*:5]-[OH;+0:6]>>[*:4]-[CH;+0:3]1-[*:5]-[O;H0;+0:6]-1.[*:1]-[SH;+0:2] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Kinetic mechanism of glutathione conjugation to leukotriene A4 by leukotriene C4 synthase. | Gupta N, Gresser MJ, Ford-Hutchinson AW | 1998 Mar 30 | 9554994 |
| Molecular cloning, expression and characterization of mouse leukotriene C4 synthase. | Lam BK, Penrose JF, Rokach J, Xu K, Baldasaro MH, Austen KF | 1996 Jun 15 | 8706658 |
| Molecular cloning and expression of human leukotriene-C4 synthase. | Welsch DJ, Creely DP, Hauser SD, Mathis KJ, Krivi GG, Isakson PC | 1994 Oct 11 | 7937884 |
| Enzymes functional in the syntheses of leukotrienes and related compounds. | Shimizu T | 1988 | 2846379 |
| Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages. | Dalli J, Vlasakov I, Riley IR, Rodriguez AR, Spur BW, Petasis NA, Chiang N, Serhan CN | 2016 Oct 25 | 27791009 |
| The catalytic formation of leukotriene C4: a critical step in inflammatory processes. | MacDonald CA, Bushnell EA, Gauld JW, Boyd RJ | 2014 Aug 14 | 24974917 |
| Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes. | Lam BK, Austen KF | 2002 Aug | 12432940 |
| Membrane localization and topology of leukotriene C4 synthase. | Christmas P, Weber BM, McKee M, Brown D, Soberman RJ | 2002 Aug 9 | 12023288 |