EC number:4.4.1.23
Enzyme
Download| EC Tree |
| 4. Lyases |
| 4.4 Carbon-sulfur lyases |
| 4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date) |
| ID: | 4.4.1.23 |
|---|---|
| Description: | 2-hydroxypropyl-CoM lyase. |
| Alternative Name: |
EaCoMT. Coenzyme M-epoxyalkane ligase. |
| Cath: | 3.30.390.30; 3.40.50.720; 3.50.50.60; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.4.1.23 |
| BRENDA Enzyme Link: | BRENDA 4.4.1.23 |
| KEGG Enzyme Link: | KEGG4.4.1.23 |
| BioCyc Enzyme Link: | BioCyc 4.4.1.23 |
| ExPASy Enzyme Link: | ExPASy4.4.1.23 |
| EC2PDB Enzyme Link: | EC2PDB 4.4.1.23 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.4.1.23 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.4.1.23 |
| IntEnz Enzyme Link: | IntEnz 4.4.1.23 |
| MEDLINE Enzyme Link: | MEDLINE 4.4.1.23 |
| RHEA:20904 | (S)-2-hydroxypropyl-coenzyme M = (S)-1,2-epoxypropane + coenzyme M |
| RULE(radius=1) | [*:1]-[S;H0;+0:2]-[CH2;+0:3]-[*:4]-[OH;+0:5]>>[*:1]-[SH;+0:2].[*:4]1-[CH2;+0:3]-[O;H0;+0:5]-1 |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Epoxyalkane: coenzyme M transferase in the ethene and vinyl chloride biodegradation pathways of mycobacterium strain JS60. | Coleman NV, Spain JC | 2003 Sep | 12949106 |
| Kinetic and microcalorimetric analysis of substrate and cofactor interactions in epoxyalkane:CoM transferase, a zinc-dependent epoxidase. | Krum JG, Ellsworth H, Sargeant RR, Rich G, Ensign SA | 2002 Apr 16 | 11939797 |
| A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation. | Allen JR, Clark DD, Krum JG, Ensign SA | 1999 Jul 20 | 10411892 |
| RHEA:19421 | (R)-2-hydroxypropyl-coenzyme M = (R)-1,2-epoxypropane + coenzyme M |
| RULE(radius=1) | [*:1]-[S;H0;+0:2]-[CH2;+0:3]-[*:4]-[OH;+0:5]>>[*:1]-[SH;+0:2].[*:4]1-[CH2;+0:3]-[O;H0;+0:5]-1 |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Epoxyalkane: coenzyme M transferase in the ethene and vinyl chloride biodegradation pathways of mycobacterium strain JS60. | Coleman NV, Spain JC | 2003 Sep | 12949106 |
| Kinetic and microcalorimetric analysis of substrate and cofactor interactions in epoxyalkane:CoM transferase, a zinc-dependent epoxidase. | Krum JG, Ellsworth H, Sargeant RR, Rich G, Ensign SA | 2002 Apr 16 | 11939797 |
| A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation. | Allen JR, Clark DD, Krum JG, Ensign SA | 1999 Jul 20 | 10411892 |