Enzyme

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     4. Lyases
        4.4 Carbon-sulfur lyases
            4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)
ID:4.4.1.3
Description:Dimethylpropiothetin dethiomethylase.
Cath: 3.90.230.10; 3.40.350.10; 2.60.120.10;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 4.4.1.3
BRENDA Enzyme Link: BRENDA 4.4.1.3
KEGG Enzyme Link: KEGG4.4.1.3
BioCyc Enzyme Link: BioCyc 4.4.1.3
ExPASy Enzyme Link: ExPASy4.4.1.3
EC2PDB Enzyme Link: EC2PDB 4.4.1.3
ExplorEnz Enzyme Link: ExplorEnz 4.4.1.3
PRIAM enzyme-specific profiles Link: PRIAM 4.4.1.3
IntEnz Enzyme Link: IntEnz 4.4.1.3
MEDLINE Enzyme Link: MEDLINE 4.4.1.3
MSA:

4.4.1.3;

Phylogenetic Tree:

4.4.1.3;

Uniprot:
M-CSA:
RHEA:19965 S,S-dimethyl-beta-propiothetin = acrylate + dimethyl sulfide + H(+)
RULE(radius=1) [*:1]-[CH2;+0:2]-[CH2;+0:3]-[S+;H0:4](-[*:5])-[*:6]>>[*:1]-[CH;+0:2]=[CH2;+0:3].[*:5]-[S;H0;+0:4]-[*:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
MARINE SULFUR CYCLE. Identification of the algal dimethyl sulfide-releasing enzyme: A missing link in the marine sulfur cycle.Alcolombri U, Ben-Dor S, Feldmesser E, Levin Y, Tawfik DS, Vardi A2015 Jun 2626113722
Biochemical, Kinetic, and Spectroscopic Characterization of Ruegeria pomeroyi DddW--A Mononuclear Iron-Dependent DMSP Lyase.Brummett AE, Schnicker NJ, Crider A, Todd JD, Dey M201525993446
Molecular insight into bacterial cleavage of oceanic dimethylsulfoniopropionate into dimethyl sulfide.Li CY, Wei TD, Zhang SH, Chen XL, Gao X, Wang P, Xie BB, Su HN, Qin QL, Zhang XY, Yu J, Zhang HH, Zhou BC, Yang GP, Zhang YZ2014 Jan 2124395783
Unusual regulation of a leaderless operon involved in the catabolism of dimethylsulfoniopropionate in Rhodobacter sphaeroides.Sullivan MJ, Curson AR, Shearer N, Todd JD, Green RT, Johnston AW2011 Jan 721249136
The dddP gene of Roseovarius nubinhibens encodes a novel lyase that cleaves dimethylsulfoniopropionate into acrylate plus dimethyl sulfide.Kirkwood M, Le Brun NE, Todd JD, Johnston AW2010 Jun20378650
Nuclear magnetic resonance analysis of [1-13C]dimethylsulfoniopropionate (DMSP) and [1-13C]acrylate metabolism by a DMSP lyase-producing marine isolate of the alpha-subclass of Proteobacteria.Ansede JH, Pellechia PJ, Yoch DC2001 Jul11425733
Metabolism of acrylate to beta-hydroxypropionate and its role in dimethylsulfoniopropionate lyase induction by a salt marsh sediment bacterium, Alcaligenes faecalis M3A.Ansede JH, Pellechia PJ, Yoch DC1999 Nov10543825