EC number:4.4.1.36
Enzyme
Download| EC Tree |
| 4. Lyases |
| 4.4 Carbon-sulfur lyases |
| 4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date) |
| ID: | 4.4.1.36 |
|---|---|
| Description: | Hercynylcysteine S-oxide lyase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.4.1.36 |
| BRENDA Enzyme Link: | BRENDA 4.4.1.36 |
| KEGG Enzyme Link: | KEGG4.4.1.36 |
| BioCyc Enzyme Link: | BioCyc 4.4.1.36 |
| ExPASy Enzyme Link: | ExPASy4.4.1.36 |
| EC2PDB Enzyme Link: | EC2PDB 4.4.1.36 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.4.1.36 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.4.1.36 |
| IntEnz Enzyme Link: | IntEnz 4.4.1.36 |
| MEDLINE Enzyme Link: | MEDLINE 4.4.1.36 |
| RHEA:42688 | AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide = A + ergothioneine + NH4(+) + pyruvate |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[NH2;+0:3])-[CH2;+0:4]-[S;H0;+0:5](-[*:6])=[O;H0;+0:7].[H+;H0:8]>>[*:1]-[C;H0;+0:2](-[CH3;+0:4])=[O;H0;+0:7].[*:6]-[SH;+0:5].[NH3;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| In vitro reconstitution of Mycobacterial ergothioneine biosynthesis. | Seebeck FP | 2010 May 19 | 20420449 |
| Mechanistic studies of a novel C-S lyase in ergothioneine biosynthesis: the involvement of a sulfenic acid intermediate. | Song H, Hu W, Naowarojna N, Her AS, Wang S, Desai R, Qin L, Chen X, Liu P | 2015 Jul 7 | 26149121 |
| Bioinformatic and biochemical characterizations of C-S bond formation and cleavage enzymes in the fungus Neurospora crassa ergothioneine biosynthetic pathway. | Hu W, Song H, Sae Her A, Bak DW, Naowarojna N, Elliott SJ, Qin L, Chen X, Liu P | 2014 Oct 17 | 25275953 |
| Genetic and metabolomic dissection of the ergothioneine and selenoneine biosynthetic pathway in the fission yeast, S. pombe, and construction of an overproduction system. | Pluskal T, Ueno M, Yanagida M | 2014 | 24828577 |