EC number:4.4.1.37

Enzyme

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     4. Lyases
        4.4 Carbon-sulfur lyases
            4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)
ID:4.4.1.37
Description:Pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase.
Alternative Name: Pyridinium-3,5-biscarboxylic acid mononucleotide sulfurtransferase.
P2TMN synthase.
P2CMN sulfurtransferase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.4.1.37
BRENDA Enzyme Link: BRENDA 4.4.1.37
KEGG Enzyme Link: KEGG4.4.1.37
BioCyc Enzyme Link: BioCyc 4.4.1.37
ExPASy Enzyme Link: ExPASy4.4.1.37
EC2PDB Enzyme Link: EC2PDB 4.4.1.37
ExplorEnz Enzyme Link: ExplorEnz 4.4.1.37
PRIAM enzyme-specific profiles Link: PRIAM 4.4.1.37
IntEnz Enzyme Link: IntEnz 4.4.1.37
MEDLINE Enzyme Link: MEDLINE 4.4.1.37

EC number:4.4.1.37

MSA:

4.4.1.37;
Phylogenetic Tree:

4.4.1.37;
Uniprot:
M-CSA:
RHEA:54892 [LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide = [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[CH2;+0:4]-[SH;+0:5].[*:6]-[O;H0;+0:7]-[P;H0;+0:8](-[*:9])(=[*:10])-[*:11].[*:12]=[C;H0;+0:13](-[*:14])-[OH;+0:15]>>[*:1]-[C;H0;+0:2](-[*:3])=[CH2;+0:4].[*:6]-[OH;+0:7].[*:9]-[P;H0;+0:8](=[*:10])(-[*:11])-[OH;+0:15].[*:12]=[C;H0;+0:13](-[*:14])-[SH;+0:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion.Desguin B, Soumillion P, Hols P, Hausinger RP2016 May 1727114550
RHEA:54788 [LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide = [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide
RULE(radius=1) [*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:4].[*:5]-[CH;+0:6](-[*:7])-[CH2;+0:8]-[SH;+0:9].[*:10]-[O;H0;+0:11]-[P;H0;+0:12](-[*:13])(=[*:14])-[*:15]>>[*:5]-[C;H0;+0:6](-[*:7])=[CH2;+0:8].[*:1]-[C;H0;+0:2](=[*:3])-[SH;+0:9].[*:10]-[OH;+0:11].[*:13]-[P;H0;+0:12](=[*:14])(-[*:15])-[OH;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion.Desguin B, Soumillion P, Hols P, Hausinger RP2016 May 1727114550