EC number:4.4.1.4
Enzyme
Download| EC Tree |
| 4. Lyases |
| 4.4 Carbon-sulfur lyases |
| 4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date) |
| ID: | 4.4.1.4 |
|---|---|
| Description: | Alliin lyase. |
| Alternative Name: |
L-cysteine sulfoxide lyase. Cysteine sulphoxide lyase. Cysteine sulfoxide lyase. Alliinase. |
| Cath: | 3.40.640.10; 3.90.1150.10; 2.10.25.30; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.4.1.4 |
| BRENDA Enzyme Link: | BRENDA 4.4.1.4 |
| KEGG Enzyme Link: | KEGG4.4.1.4 |
| BioCyc Enzyme Link: | BioCyc 4.4.1.4 |
| ExPASy Enzyme Link: | ExPASy4.4.1.4 |
| EC2PDB Enzyme Link: | EC2PDB 4.4.1.4 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.4.1.4 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.4.1.4 |
| IntEnz Enzyme Link: | IntEnz 4.4.1.4 |
| MEDLINE Enzyme Link: | MEDLINE 4.4.1.4 |
| RHEA:54688 | alliin = 2-aminoprop-2-enoate + allylsulfenate |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[CH2;+0:4]-[S;H0;+0:5](-[*:6])=[O;H0;+0:7]>>[*:1]-[C;H0;+0:2](-[*:3])=[CH2;+0:4].[*:6]-[S;H0;+0:5]-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Two structures of alliinase from Alliium sativum L.: apo form and ternary complex with aminoacrylate reaction intermediate covalently bound to the PLP cofactor. | Shimon LJ, Rabinkov A, Shin I, Miron T, Mirelman D, Wilchek M, Frolow F | 2007 Feb 16 | 17174334 |
| Purification, characterization, and crystallization of alliinase from garlic. | Kuettner EB, Hilgenfeld R, Weiss MS | 2002 Jun 15 | 12051663 |
| RHEA:20141 | an S-alkyl-L-cysteine S-oxide = 2-aminoprop-2-enoate + an S-alkyl sulfenate |
| RULE(radius=1) | [*:1]-[S;H0;+0:2](=[O;H0;+0:3])-[CH2;+0:4]-[CH;+0:5](-[*:6])-[*:7]>>[*:6]-[C;H0;+0:5](-[*:7])=[CH2;+0:4].[*:1]-[S;H0;+0:2]-[OH;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Two structures of alliinase from Alliium sativum L.: apo form and ternary complex with aminoacrylate reaction intermediate covalently bound to the PLP cofactor. | Shimon LJ, Rabinkov A, Shin I, Miron T, Mirelman D, Wilchek M, Frolow F | 2007 Feb 16 | 17174334 |
| Purification, characterization, and crystallization of alliinase from garlic. | Kuettner EB, Hilgenfeld R, Weiss MS | 2002 Jun 15 | 12051663 |