EC number:4.4.1.9
Enzyme
Download| EC Tree |
| 4. Lyases |
| 4.4 Carbon-sulfur lyases |
| 4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date) |
| ID: | 4.4.1.9 |
|---|---|
| Description: | L-3-cyanoalanine synthase. |
| Alternative Name: |
Beta-cyanoalanine synthase. Beta-cyano-L-alanine synthase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.4.1.9 |
| BRENDA Enzyme Link: | BRENDA 4.4.1.9 |
| KEGG Enzyme Link: | KEGG4.4.1.9 |
| BioCyc Enzyme Link: | BioCyc 4.4.1.9 |
| ExPASy Enzyme Link: | ExPASy4.4.1.9 |
| EC2PDB Enzyme Link: | EC2PDB 4.4.1.9 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.4.1.9 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.4.1.9 |
| IntEnz Enzyme Link: | IntEnz 4.4.1.9 |
| MEDLINE Enzyme Link: | MEDLINE 4.4.1.9 |
| RHEA:17821 | hydrogen cyanide + L-cysteine = 3-cyano-L-alanine + H(+) + hydrogen sulfide |
| RULE(radius=1) | [*:1]#[CH;+0:2].[*:3]-[CH2;+0:4]-[SH;+0:5]>>[*:3]-[CH2;+0:4]-[C;H0;+0:2]#[*:1].[SH2;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Stereochemistry of the beta-cyanoalanine synthetase and S-alkylcysteine lyase reactions. | Tsai MD, Weaver J, Floss HG, Conn EE, Creveling RK, Mazelis M | 1978 Oct | 718168 |
| Biochemical properties of nematode O-acetylserine(thiol)lyase paralogs imply their distinct roles in hydrogen sulfide homeostasis. | Vozdek R, Hnízda A, Krijt J, Será L, Kožich V | 2013 Dec | 24100226 |
| Expression of MdCAS1 and MdCAS2, encoding apple beta-cyanoalanine synthase homologs, is concomitantly induced during ripening and implicates MdCASs in the possible role of the cyanide detoxification in Fuji apple (Malus domestica Borkh.) fruits. | Han SE, Seo YS, Kim D, Sung SK, Kim WT | 2007 Aug | 17333023 |