EC number:4.99.1.12
Enzyme
Download| EC Tree |
| 4. Lyases |
| 4.99 Other lyases |
| 4.99.1 Sole sub-subclass for lyases that do not belong in the other subclasses |
| ID: | 4.99.1.12 |
|---|---|
| Description: | Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel chelatase. |
| Alternative Name: |
P2TMN nickel chelatase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.99.1.12 |
| BRENDA Enzyme Link: | BRENDA 4.99.1.12 |
| KEGG Enzyme Link: | KEGG4.99.1.12 |
| BioCyc Enzyme Link: | BioCyc 4.99.1.12 |
| ExPASy Enzyme Link: | ExPASy4.99.1.12 |
| EC2PDB Enzyme Link: | EC2PDB 4.99.1.12 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.99.1.12 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.99.1.12 |
| IntEnz Enzyme Link: | IntEnz 4.99.1.12 |
| MEDLINE Enzyme Link: | MEDLINE 4.99.1.12 |
EC number:4.99.1.12
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:54784 | Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide = Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide |
| RULE(radius=1) | [OH;+0:1]-[C;H0;+0:2]1=[S+;H0:3]-[Ni-;H0:4]2-[S;H0;+0:5]-[*:6]-[*:7]:[c;H0;+0:8]-2:[*:9]-1>>[Ni+2;H0:4].[O;H0;+0:1]=[C;H0;+0:2](-[SH;+0:3])-[*:9]:[cH;+0:8]:[*:7]-[*:6]-[SH;+0:5] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion. | Desguin B, Soumillion P, Hols P, Hausinger RP | 2016 May 17 | 27114550 |