EC number:4.99.1.3
Enzyme
Download| EC Tree |
| 4. Lyases |
| 4.99 Other lyases |
| 4.99.1 Sole sub-subclass for lyases that do not belong in the other subclasses |
| ID: | 4.99.1.3 |
|---|---|
| Description: | Sirohydrochlorin cobaltochelatase. |
| Alternative Name: |
Cobaltochelatase. Anaerobic cobalt chelatase. |
| Cath: | 3.40.50.140; 3.40.50.1400; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.99.1.3 |
| BRENDA Enzyme Link: | BRENDA 4.99.1.3 |
| KEGG Enzyme Link: | KEGG4.99.1.3 |
| BioCyc Enzyme Link: | BioCyc 4.99.1.3 |
| ExPASy Enzyme Link: | ExPASy4.99.1.3 |
| EC2PDB Enzyme Link: | EC2PDB 4.99.1.3 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.99.1.3 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.99.1.3 |
| IntEnz Enzyme Link: | IntEnz 4.99.1.3 |
| MEDLINE Enzyme Link: | MEDLINE 4.99.1.3 |
| RHEA:26269 | Co-precorrin-2 + 3 H(+) = Co(2+) + precorrin-2 |
| RULE(radius=1) | [*:1]=[N+;H0:2](-[*:3])-[Co-2;H0:4]12-[N+;H0:5]3=[C;H0;+0:6](-[*:7]=[*:8]-[N;H0;+0:9]-1-[*:10])-[CH;+0:11](-[*:12])-[C;H0;+0:13](-[*:14])=[C;H0;+0:15]-3-[*:16]-[*:17]:[n;H0;+0:18]-2:[*:19].[H+;H0:20].[H+;H0:21].[H+;H0:22]>>([*:10]-[NH;+0:9]-[*:8]=[*:7]-[c;H0;+0:6]1:[nH;+0:5]:[c;H0;+0:15](-[*:16]-[*:17]:[nH;+0:18]:[*:19]):[c;H0;+0:13](-[*:14]):[c;H0;+0:11]:1-[*:12].[*:1]=[N;H0;+0:2]-[*:3]).[Co+2;H0:4] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Common chelatase design in the branched tetrapyrrole pathways of heme and anaerobic cobalamin synthesis. | Schubert HL, Raux E, Wilson KS, Warren MJ | 1999 Aug 17 | 10451360 |
| A role for Salmonella typhimurium cbiK in cobalamin (vitamin B12) and siroheme biosynthesis. | Raux E, Thermes C, Heathcote P, Rambach A, Warren MJ | 1997 May | 9150215 |
| RHEA:15893 | Co-sirohydrochlorin + 2 H(+) = Co(2+) + sirohydrochlorin |
| RULE(radius=1) | [*:1]-[C;H0;+0:2]1=[C;H0;+0:3](-[*:4])-[C;H0;+0:5]2=[N+;H0:6]3-[C;H0;+0:7]-1=[CH;+0:8]-[*:9]:[n;H0;+0:10]1:[*:11]-[CH;+0:12]=[C;H0;+0:13]4-[*:14]-[*:15]-[C;H0;+0:16]5=[N+;H0:17]-4-[Co-2;H0:18]-3-1-[N;H0;+0:19]1-[C;H0;+0:20](=[CH;+0:21]-5)-[*:22]-[*:23]-[C;H0;+0:24]-1=[CH;+0:25]-2.[H+;H0:26].[H+;H0:27]>>[*:1]-[c;H0;+0:2]1:[c;H0;+0:3](-[*:4]):[c;H0;+0:5]2:[cH;+0:25]:[c;H0;+0:24]3:[nH;+0:19]:[c;H0;+0:20](:[cH;+0:21]:[c;H0;+0:16]4:[n;H0;+0:17]:[c;H0;+0:13](:[cH;+0:12]:[*:11]:[nH;+0:10]:[*:9]:[cH;+0:8]:[c;H0;+0:7]:1:[n;H0;+0:6]:2)-[*:14]-[*:15]-4)-[*:22]-[*:23]-3.[Co+2;H0:18] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A story of chelatase evolution: identification and characterization of a small 13-15-kDa "ancestral" cobaltochelatase (CbiXS) in the archaea. | Brindley AA, Raux E, Leech HK, Schubert HL, Warren MJ | 2003 Jun 20 | 12686546 |
| Common chelatase design in the branched tetrapyrrole pathways of heme and anaerobic cobalamin synthesis. | Schubert HL, Raux E, Wilson KS, Warren MJ | 1999 Aug 17 | 10451360 |
| The biosynthesis of adenosylcobalamin (vitamin B12). | Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC | 2002 Aug | 12195810 |