Enzyme

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     5. Isomerases
        5.1 Racemases and epimerases
            5.1.1 Acting on amino acids and derivatives
ID:5.1.1.18
Description:Serine racemase.
Prosite: PDOC00149;
PDB:
PDBScop
Cath: 3.40.50.1100;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 5.1.1.18
BRENDA Enzyme Link: BRENDA 5.1.1.18
KEGG Enzyme Link: KEGG5.1.1.18
BioCyc Enzyme Link: BioCyc 5.1.1.18
ExPASy Enzyme Link: ExPASy5.1.1.18
EC2PDB Enzyme Link: EC2PDB 5.1.1.18
ExplorEnz Enzyme Link: ExplorEnz 5.1.1.18
PRIAM enzyme-specific profiles Link: PRIAM 5.1.1.18
IntEnz Enzyme Link: IntEnz 5.1.1.18
MEDLINE Enzyme Link: MEDLINE 5.1.1.18
MSA:

5.1.1.18;

Phylogenetic Tree:

5.1.1.18;

Uniprot:
M-CSA:
RHEA:10980 L-serine = D-serine
RULE(radius=1)
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Structural basis for the broad specificity of a new family of amino-acid racemases.Espaillat A, Carrasco-López C, Bernardo-García N, Pietrosemoli N, Otero LH, Álvarez L, de Pedro MA, Pazos F, Davis BM, Waldor MK, Hermoso JA, Cava F2014 Jan24419381
Inhibition of serine and proline racemases by substrate-product analogues.Harty M, Nagar M, Atkinson L, Legay CM, Derksen DJ, Bearne SL2014 Jan 124314397
Catalytic mechanism of serine racemase from Dictyostelium discoideum.Ito T, Maekawa M, Hayashi S, Goto M, Hemmi H, Yoshimura T2013 Mar23269477
Modulating the function of human serine racemase and human serine dehydratase by protein engineering.Wang CY, Ku SC, Lee CC, Wang AH2012 Nov23112234
The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding.Smith MA, Mack V, Ebneth A, Moraes I, Felicetti B, Wood M, Schonfeld D, Mather O, Cesura A, Barker J2010 Apr 2320106978
Crystal structure of a homolog of mammalian serine racemase from Schizosaccharomyces pombe.Goto M, Yamauchi T, Kamiya N, Miyahara I, Yoshimura T, Mihara H, Kurihara T, Hirotsu K, Esaki N2009 Sep 1819640845
Serine racemase with catalytically active lysinoalanyl residue.Yamauchi T, Goto M, Wu HY, Uo T, Yoshimura T, Mihara H, Kurihara T, Miyahara I, Hirotsu K, Esaki N2009 Apr19155267
Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity.Foltyn VN, Bendikov I, De Miranda J, Panizzutti R, Dumin E, Shleper M, Li P, Toney MD, Kartvelishvily E, Wolosker H2005 Jan 2115536068