EC number:5.1.3.17
Enzyme
Download| EC Tree |
| 5. Isomerases |
| 5.1 Racemases and epimerases |
| 5.1.3 Acting on carbohydrates and derivatives |
| ID: | 5.1.3.17 |
|---|---|
| Description: | Heparosan-N-sulfate-glucuronate 5-epimerase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 5.1.3.17 |
| BRENDA Enzyme Link: | BRENDA 5.1.3.17 |
| KEGG Enzyme Link: | KEGG5.1.3.17 |
| BioCyc Enzyme Link: | BioCyc 5.1.3.17 |
| ExPASy Enzyme Link: | ExPASy5.1.3.17 |
| EC2PDB Enzyme Link: | EC2PDB 5.1.3.17 |
| ExplorEnz Enzyme Link: | ExplorEnz 5.1.3.17 |
| PRIAM enzyme-specific profiles Link: | PRIAM 5.1.3.17 |
| IntEnz Enzyme Link: | IntEnz 5.1.3.17 |
| MEDLINE Enzyme Link: | MEDLINE 5.1.3.17 |
| RHEA:20197 | [heparosan-N-sulfate](n) = [heparan-N-sulfate](n) |
| RULE(radius=1) | |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Uncovering biphasic catalytic mode of C5-epimerase in heparan sulfate biosynthesis. | Sheng J, Xu Y, Dulaney SB, Huang X, Liu J | 2012 Jun 15 | 22528493 |
| Using engineered 2-O-sulfotransferase to determine the activity of heparan sulfate C5-epimerase and its mutants. | Li K, Bethea HN, Liu J | 2010 Apr 9 | 20118238 |
| Heparan sulfate C5-epimerase is essential for heparin biosynthesis in mast cells. | Feyerabend TB, Li JP, Lindahl U, Rodewald HR | 2006 Apr | 16532012 |
| Cloning, Golgi localization, and enzyme activity of the full-length heparin/heparan sulfate-glucuronic acid C5-epimerase. | Crawford BE, Olson SK, Esko JD, Pinhal MA | 2001 Jun 15 | 11279150 |
| Biosynthesis of heparin/heparan sulphate: mechanism of epimerization of glucuronyl C-5. | Hagner-Mcwhirter A, Lindahl U, Li Jp | 2000 Apr 1 | 10727403 |
| Biosynthesis of heparin. Assay and properties of the microsomal uronosyl C-5 epimerase. | Bäckström G, Höök M, Lindahl U, Feingold DS, Malmström A, Rodén L, Jacobsson I | 1979 Apr 25 | 107165 |