EC number:5.2.1.8

Enzyme

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EC Tree
     5. Isomerases
        5.2 cis-trans-Isomerases
            5.2.1 cis-trans Isomerases (only sub-subclass identified to date)
ID:5.2.1.8
Description:Peptidylprolyl isomerase.
Alternative Name: Rotamase.
PPIase.
Peptidylprolyl cis-trans isomerase.
Peptidyl-prolyl cis-trans isomerase.
Cyclophilin.
Prosite: PDOC00154; PDOC00840; PDOC00426;
PDB:
PDBScop
6FF4 8089607; 8089608; 8064956; 8064957; 8044675; 8051848; 8044842; 8051197; 8052534; 8052535; 8024083; 8036462; 8028726; 8041105; 8050374; 8053277; 8028316; 8040695; 8061966; 8061967; 8021550; 8033930;
3H9R 8080452; 8080453; 8023594; 8035974;
4C02 8080452; 8080453; 8022484; 8034864;
3MDY 8080450; 8080451; 8023594; 8035974; 8080450; 8080451; 8023594; 8035974;
5Z58 8061966; 8061967; 8089607; 8089608; 8029369; 8041748; 8031615; 8043993; 8028726; 8041105; 8050374; 8053277; 8029370; 8041749; 8029369; 8041748; 8022947; 8035327; 8028316; 8040695; 8023813; 8036193; 8055092; 8055093; 8029372; 8041751; 8029370; 8041749; 8044675; 8051848; 8044842; 8051197; 8052534; 8052535; 8029368; 8041747; 8029372; 8041751; 8084946; 8090834; 8029368; 8041747;
 » show all
Cath: 1.10.150.160; 1.10.238.10; 1.10.287.2490; 1.10.287.460; 1.10.3120.10; 1.10.4030.10; 1.10.4030.30; 1.10.720.80; 1.10.8.10; 1.10.8.1040;

3D structure

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PDB

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6FF4; 3H9R; 4C02; 3MDY; 5Z58; 2KGJ; 5TVL; 3JB9; 1IX5; 1W74; 5MQF; 1KT1; 3O5K; 4W9P; 4W9O; 4DRK; 3O5M; 3O5I; 4DRH; 4DRI; 5OBK; 5DIV; 5DIU; 5DIT; 5BXJ; 4W9Q; 4TX0; 4TW7; 4TW6; 4R0X; 4JFM; 4JFL; 4JFK; 4JFJ; 4JFI; 4DRQ; 4DRP; 4DRO; 4DRN; 4DRM; 3O5R; 3O5Q; 3O5P; 3O5O; 3O5L; 3O5J; 3O5G; 3O5F; 3O5E; 3O5D; 5OMP; 5NJX; 1KT0; 1VAI; 1V9T; 1J2A; 1CLH; 1C5F; 1A58; 1A33; 2RMC; 5O9Z; 1QOI; 1MZW; 3ICI; 3ICH; 1CYN; 1H0P; 2VRH; 6ID0; 6ICZ; 6ID1; 5ZR0; 1L1P; 1W26; 1Y0O; 1U79; 6FF7; 2ESL; 1JVW; 1T11; 1J6Y; 1Q6I; 1Q6H; 1Q6U; 1HXV; 1N1A; 4TW8; 4LAW; 4LAV; 4LAY; 4LAX; 1Q1C; 5A0E; 2Z6W; 5NWO; 5CCS; 5CCR; 5CCQ; 5CCN; 5CBW; 5CBV; 5CBU; 5CBT; 4ZSD; 4ZSC; 4XNC; 4O8I; 4O8H; 4J5E; 4J5D; 4J5C; 4J5B; 4J5A; 4J59; 4J58; 3RDC; 3RDB; 3RDA; 3RD9; 3RCL; 3RCK; 3RCI; 3RCG; 3RCF; 3R59; 3R57; 3R56; 3R54; 3R4G; 3R49; 3QYU; 2BIU; 2BIT; 1P5Q; 1QZ2; 6D6S; 5OWJ; 5OWI; 1MF8; 6DUN; 4TYO; 4TNS; 3KAC; 3JYJ; 3IKG; 3IKD; 3IK8; 3I6C; 5GPH; 2RUR; 2RUQ; 2RUD; 2RUC; 1NMW; 5UY9; 4U86; 4U85; 4U84; 4QIB; 3WH0; 3TDB; 3TCZ; 3TC5; 3OOB; 3ODK; 3NTP; 3KCE; 3KAI; 3KAH; 3KAG; 3KAF; 3KAD; 3KAB; 2ZR6; 2ZR5; 2ZR4; 2ZQV; 2ZQU; 2ZQT; 2ZQS; 2XPB; 2XPA; 2XP9; 2XP8; 2XP7; 2XP6; 2XP5; 2XP4; 2XP3; 2Q5A; 2ITK; 2F21; 1ZCN; 1PIN; 1NMV; 1F8A; 4FAP; 3FAP; 1TCO; 2A2N; 2PV2; 1M5Y; 2PV3; 2PV1; 3UCH; 2R99; 1ZMF; 2RSE; 2FAP; 1NSG; 1FAP; 1B6C; 1J4R; 1QPL; 1QPF; 1FKI; 1EYM; 1D7J; 1D7I; 1D7H; 1D6O; 1BL4; 1A7X; 5I7Q; 5I7P; 4N19; 4IPX; 4DH0; 2PPP; 2PPO; 2PPN; 2ND5; 2FKE; 2DG9; 2DG4; 2DG3; 1J4I; 1J4H; 1FKT; 1FKS; 1FKR; 1FKJ; 1FKH; 1FKG; 1FKF; 1FKD; 1FKB; 1F40; 1BKF; 1ZKC; 2OJU; 2OK3; 1XYH; 1ROU; 1ROT; 5GPG; 5D75; 2MPH; 1PBK; 1YAT; 4IQC; 4IQ2; 5HKG; 1C9H; 1FKL; 1FKK; 2IGW; 2IGV; 1E8K; 1E3B; 1DYW; 2MLZ; 1IIP; 1IHG; 2X7K; 2K7N; 1XWN; 2VCD; 2UZ5; 1FD9; 3UI6; 3UI5; 3UI4; 1FJD; 1EQ3; 1IST; 1VDN; 1JNT; 1JNS; 3RFY; 1M63; 3ODL; 3ODI; 2RMB; 2RMA; 1AWV; 1AWT; 1AWR; 2X2C; 5T9U; 1M9Y; 1M9X; 2X2D; 2X2A; 1YND; 1VBT; 1RMH; 1NMK; 1M9F; 1M9E; 1M9D; 1M9C; 1AK4; 6GJY; 6GJR; 6GJP; 6GJN; 6GJM; 6GJL; 6GJJ; 6GJI; 6BTA; 5WC7; 5TA4; 5T9Z; 5T9W; 5NOZ; 5NOY; 5NOX; 5NOW; 5NOV; 5NOU; 5NOT; 5NOS; 5NOR; 5NOQ; 5LUD; 5KV7; 5KV6; 5KV5; 5KV4; 5KV3; 5KV2; 5KV1; 5KV0; 5KUZ; 5KUW; 5KUV; 5KUU; 5KUS; 5KUR; 5KUQ; 5KUO; 5KUN; 5KUL; 5FJB; 5F66; 5CYH; 4YUP; 4YUO; 4YUN; 4YUM; 4YUL; 4YUK; 4YUJ; 4YUI; 4YUH; 4YUG; 4N1S; 4N1R; 4N1Q; 4N1P; 4N1O; 4N1N; 4N1M; 4IPZ; 4CYH; 3RDD; 3K0R; 3K0Q; 3K0P; 3K0O; 3K0N; 3K0M; 3CYH; 2XGY; 2X25; 2N0T; 2MZU; 2MS4; 2CYH; 2CPL; 2ALF; 1W8V; 1W8L; 1VBS; 1OCA; 1MIK; 1FGL; 1CWO; 1CWM; 1CWL; 1CWK; 1CWJ; 1CWI; 1CWH; 1CWF; 1CWC; 1CWB; 1CWA; 1BCK; 1AWU; 1AWS; 1AWQ; 6FK1; 6BHF; 5TA2; 5MGX; 5JHE; 5J6E; 5I98; 5HWC; 5HWB; 5HW8; 5HW7; 5HW6; 5HUA; 5HTG; 5HTF; 5HT1; 5HSV; 5EZ1; 4WO7; 4TOT; 4R3E; 4ODR; 4ODQ; 4ODP; 4NNR; 4MSP; 4LQW; 4I9Y; 4DT4; 4DRJ; 4DIP; 4DGE; 4DGD; 4DGC; 4DGB; 4DGA; 4BF8; 3RFW; 3PRD; 3PRB; 3PRA; 3PR9; 3KZ7; 3K2C; 3JYM; 3JXV; 3EY6; 3CYS; 3B7X; 2WLW; 2WFJ; 2WFI; 2RS4; 2PBC; 2OSE; 2NUL; 2MLY; 2MLX; 2MF9; 2MC9; 2M2A; 2LKN; 2KR7; 2KFW; 2K8I; 2JZV; 2IF4; 2HQ6; 2HE9; 2GW2; 2F4E; 2F2D; 2D9F; 2CMT; 2CK1; 2AWG; 1ZKF; 1ZK6; 1W8M; 1LOP;

References

External Links

UniProtKB Enzyme Link: UniProtKB 5.2.1.8
BRENDA Enzyme Link: BRENDA 5.2.1.8
KEGG Enzyme Link: KEGG5.2.1.8
BioCyc Enzyme Link: BioCyc 5.2.1.8
ExPASy Enzyme Link: ExPASy5.2.1.8
EC2PDB Enzyme Link: EC2PDB 5.2.1.8
ExplorEnz Enzyme Link: ExplorEnz 5.2.1.8
PRIAM enzyme-specific profiles Link: PRIAM 5.2.1.8
IntEnz Enzyme Link: IntEnz 5.2.1.8
MEDLINE Enzyme Link: MEDLINE 5.2.1.8

EC number:5.2.1.8

MSA:

5.2.1.8;
Phylogenetic Tree:

5.2.1.8;
Uniprot:
M-CSA:
RHEA:16237 [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)
RULE(radius=1)
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
[Determination of enzymatic catalysis for the cis-trans-isomerization of peptide binding in proline-containing peptides].Fischer G, Bang H, Mech C19846395866
The refolding of urea-denatured ribonuclease A is catalyzed by peptidyl-prolyl cis-trans isomerase.Fischer G, Bang H1985 Mar 223882150
Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin.Takahashi N, Hayano T, Suzuki M1989 Feb 22644542
Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins.Fischer G, Wittmann-Liebold B, Lang K, Kiefhaber T, Schmid FX1989 Feb 22492638