EC number:5.3.1.5

Enzyme

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     5. Isomerases
        5.3 Intramolecular oxidoreductases
            5.3.1 Interconverting aldoses and ketoses, and related compounds
ID:5.3.1.5
Description:Xylose isomerase.
Alternative Name: D-xylose ketoisomerase.
Prosite: PDOC00156;
PDB:
PDBScop
2GYI 8031436; 8043814; 8031436; 8043814;
1XYM 8031436; 8043814; 8031436; 8043814;
1XYL 8031436; 8043814; 8031436; 8043814;
1XYC 8031436; 8043814; 8031436; 8043814;
1XYB 8031436; 8043814; 8031436; 8043814;
 » show all
Cath: 3.20.20.150;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 5.3.1.5
BRENDA Enzyme Link: BRENDA 5.3.1.5
KEGG Enzyme Link: KEGG5.3.1.5
BioCyc Enzyme Link: BioCyc 5.3.1.5
ExPASy Enzyme Link: ExPASy5.3.1.5
EC2PDB Enzyme Link: EC2PDB 5.3.1.5
ExplorEnz Enzyme Link: ExplorEnz 5.3.1.5
PRIAM enzyme-specific profiles Link: PRIAM 5.3.1.5
IntEnz Enzyme Link: IntEnz 5.3.1.5
MEDLINE Enzyme Link: MEDLINE 5.3.1.5

EC number:5.3.1.5

MSA:

5.3.1.5;
Phylogenetic Tree:

5.3.1.5;
Uniprot:
M-CSA:
RHEA:28546 D-glucose = D-fructose
RULE(radius=1) [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[CH;+0:5](-[*:6])-[*:7]>>[*:1]-[O;H0;+0:2]-[C;H0;+0:5](-[*:6])(-[*:7])-[CH2;+0:3]-[*:4]
Reaction
Core-to-Core More
RHEA:22816 D-xylose = D-xylulose
RULE(radius=1) [*:1]-[CH;+0:2]1-[*:3]-[*:4]-[CH;+0:5](-[OH;+0:6])-[*:7]-[O;H0;+0:8]-1>>[*:1]-[CH2;+0:2]-[*:3]-[*:4]-[C;H0;+0:5](=[O;H0;+0:6])-[*:7]-[OH;+0:8]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Role of the divalent metal ion in sugar binding, ring opening, and isomerization by D-xylose isomerase: replacement of a catalytic metal by an amino acid.Allen KN, Lavie A, Glasfeld A, Tanada TN, Gerrity DP, Carlson SC, Farber GK, Petsko GA, Ringe D1994 Feb 157906142
X-ray analysis of D-xylose isomerase at 1.9 A: native enzyme in complex with substrate and with a mechanism-designed inactivator.Carrell HL, Glusker JP, Burger V, Manfre F, Tritsch D, Biellmann JF1989 Jun2734296
Observations of reaction intermediates and the mechanism of aldose-ketose interconversion by D-xylose isomerase.Collyer CA, Blow DM1990 Feb2304904
A metal-mediated hydride shift mechanism for xylose isomerase based on the 1.6 A Streptomyces rubiginosus structures with xylitol and D-xylose.Whitlow M, Howard AJ, Finzel BC, Poulos TL, Winborne E, Gilliland GL19912006134