EC number:5.3.3.1
| ID: | 5.3.3.1 |
|---|---|
| Description: | Steroid Delta-isomerase. |
| Alternative Name: |
Steroid isomerase. Hydroxysteroid isomerase. Delta(5)-steroid isomerase. Delta(5)-3-oxosteroid isomerase. Delta(5)-3-ketosteroid isomerase. Delta(5)-3-keto steroid isomerase. 3-oxosteroid isomerase. |
| Cath: | 3.10.450.50; 3.30.410.10; 3.50.50.60; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 5.3.3.1 |
| BRENDA Enzyme Link: | BRENDA 5.3.3.1 |
| KEGG Enzyme Link: | KEGG5.3.3.1 |
| BioCyc Enzyme Link: | BioCyc 5.3.3.1 |
| ExPASy Enzyme Link: | ExPASy5.3.3.1 |
| EC2PDB Enzyme Link: | EC2PDB 5.3.3.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 5.3.3.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 5.3.3.1 |
| IntEnz Enzyme Link: | IntEnz 5.3.3.1 |
| MEDLINE Enzyme Link: | MEDLINE 5.3.3.1 |
| RHEA:32187 | cholest-5-en-3-one = cholest-4-en-3-one |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[CH2;+0:3]-[*:4])=[CH;+0:5]-[*:6]>>[*:1]-[C;H0;+0:2](-[CH2;+0:5]-[*:6])=[CH;+0:3]-[*:4] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase. | Yang X, Dubnau E, Smith I, Sampson NS | 2007 Aug 7 | 17630785 |
| Cholesterol oxidase: structure and function. | Vrielink A | 2010 | 20213543 |
| RHEA:14709 | a 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[C;H0;+0:3](-[*:4])=[CH;+0:5]-[*:6]>>[*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[CH2;+0:5]-[*:6] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Water in the active site of ketosteroid isomerase. | Hanoian P, Hammes-Schiffer S | 2011 Aug 9 | 21710970 |
| Enzymatic mechanisms for catalysis of enolization: ketosteroid isomerase. | Pollack RM | 2004 Oct | 15381400 |
| Cholesterol oxidase is required for virulence of Mycobacterium tuberculosis. | Brzostek A, Dziadek B, Rumijowska-Galewicz A, Pawelczyk J, Dziadek J | 2007 Oct | 17651430 |
| Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase. | Yang X, Dubnau E, Smith I, Sampson NS | 2007 Aug 7 | 17630785 |
| Cholesterol oxidase: sources, physical properties and analytical applications. | MacLachlan J, Wotherspoon AT, Ansell RO, Brooks CJ | 2000 Apr | 10822008 |
| Crystal structure determination of cholesterol oxidase from Streptomyces and structural characterization of key active site mutants. | Yue QK, Kass IJ, Sampson NS, Vrielink A | 1999 Apr 6 | 10194345 |