EC number:5.3.3.12
| ID: | 5.3.3.12 | ||
|---|---|---|---|
| Description: | L-dopachrome isomerase. | ||
| Alternative Name: |
Tyrosinase-related protein 2. TRP. L-dopachrome-methyl ester tautomerase. Dopachrome tautomerase. Dopachrome rearranging enzyme. Dopachrome oxidoreductase. Dopachrome keto-enol isomerase. Dopachrome isomerase. Dopachrome Delta-isomerase. Dopachrome Delta(7),Delta(2)-isomerase. Dopachrome conversion factor. DCT. DCF. | ||
| Prosite: | PDOC00398; | ||
| PDB: |
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| Cath: | 3.30.429.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 5.3.3.12 |
| BRENDA Enzyme Link: | BRENDA 5.3.3.12 |
| KEGG Enzyme Link: | KEGG5.3.3.12 |
| BioCyc Enzyme Link: | BioCyc 5.3.3.12 |
| ExPASy Enzyme Link: | ExPASy5.3.3.12 |
| EC2PDB Enzyme Link: | EC2PDB 5.3.3.12 |
| ExplorEnz Enzyme Link: | ExplorEnz 5.3.3.12 |
| PRIAM enzyme-specific profiles Link: | PRIAM 5.3.3.12 |
| IntEnz Enzyme Link: | IntEnz 5.3.3.12 |
| MEDLINE Enzyme Link: | MEDLINE 5.3.3.12 |
| RHEA:13041 | L-dopachrome = 5,6-dihydroxyindole-2-carboxylate |
| RULE(radius=1) | [*:1]-[CH;+0:2]1-[CH2;+0:3]-[C;H0;+0:4]2=[CH;+0:5]-[C;H0;+0:6](=[O;H0;+0:7])-[C;H0;+0:8](=[O;H0;+0:9])-[CH;+0:10]=[C;H0;+0:11]-2-[NH;+0:12]-1>>[*:1]-[c;H0;+0:2]1:[cH;+0:3]:[c;H0;+0:4]2:[cH;+0:5]:[c;H0;+0:8](-[OH;+0:9]):[c;H0;+0:6](-[OH;+0:7]):[cH;+0:10]:[c;H0;+0:11]:2:[nH;+0:12]:1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Rapid purification and characterization of L-dopachrome-methyl ester tautomerase (macrophage-migration-inhibitory factor) from Trichinella spiralis, Trichuris muris and Brugia pahangi. | Pennock JL, Behnke JM, Bickle QD, Devaney E, Grencis RK, Isaac RE, Joshua GW, Selkirk ME, Zhang Y, Meyer DJ | 1998 Nov 1 | 9794786 |
| Molecular mechanism for catalysis by a new zinc-enzyme, dopachrome tautomerase. | Solano F, Jiménez-Cervantes C, Martínez-Liarte JH, García-Borrón JC, Jara JR, Lozano JA | 1996 Jan 15 | 8573077 |
| A tautomerase-null macrophage migration-inhibitory factor (MIF) gene knock-in mouse model reveals that protein interactions and not enzymatic activity mediate MIF-dependent growth regulation. | Fingerle-Rowson G, Kaleswarapu DR, Schlander C, Kabgani N, Brocks T, Reinart N, Busch R, Schütz A, Lue H, Du X, Liu A, Xiong H, Chen Y, Nemajerova A, Hallek M, Bernhagen J, Leng L, Bucala R | 2009 Apr | 19188446 |
| Macrophage migration inhibitory factor of the parasitic nematode Trichinella spiralis. | Tan TH, Edgerton SA, Kumari R, McAlister MS, Roe SM, Nagl S, Pearl LH, Selkirk ME, Bianco AE, Totty NF, Engwerda C, Gray CA, Meyer DJ | 2001 Jul 15 | 11439086 |