EC number:5.3.3.8
| ID: | 5.3.3.8 |
|---|---|
| Description: | Delta(3)-Delta(2)-enoyl-CoA isomerase. |
| Alternative Name: |
Dodecenoyl-CoA isomerase. Dodecenoyl-CoA Delta-isomerase. Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase. Delta(3),Delta(2)-enoyl-CoA isomerase. Acetylene-allene isomerase. 3,2-trans-enoyl-CoA isomerase. |
| Cath: | 1.10.1040.10; 1.10.1040.50; 1.10.12.10; 1.20.5.140; 1.20.5.1400; 1.20.5.30; 1.20.5.3020; 3.40.50.720; 3.90.226.10; 1.20.80.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 5.3.3.8 |
| BRENDA Enzyme Link: | BRENDA 5.3.3.8 |
| KEGG Enzyme Link: | KEGG5.3.3.8 |
| BioCyc Enzyme Link: | BioCyc 5.3.3.8 |
| ExPASy Enzyme Link: | ExPASy5.3.3.8 |
| EC2PDB Enzyme Link: | EC2PDB 5.3.3.8 |
| ExplorEnz Enzyme Link: | ExplorEnz 5.3.3.8 |
| PRIAM enzyme-specific profiles Link: | PRIAM 5.3.3.8 |
| IntEnz Enzyme Link: | IntEnz 5.3.3.8 |
| MEDLINE Enzyme Link: | MEDLINE 5.3.3.8 |
| RHEA:45900 | a (3Z)-enoyl-CoA = a (2E)-enoyl-CoA |
| RULE(radius=1) | [*:1]-[CH;+0:2]=[CH;+0:3]-[CH2;+0:4]-[*:5]>>[*:1]-[CH2;+0:2]-[CH;+0:3]=[CH;+0:4]-[*:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Peroxisomal bifunctional protein from rat liver is a trifunctional enzyme possessing 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and delta 3, delta 2-enoyl-CoA isomerase activities. | Palosaari PM, Hiltunen JK | 1990 Feb 15 | 2303409 |
| RHEA:45228 | a (3E)-enoyl-CoA = a (2E)-enoyl-CoA |
| RULE(radius=1) | [*:1]-[CH;+0:2]=[CH;+0:3]-[CH2;+0:4]-[*:5]>>[*:1]-[CH2;+0:2]-[CH;+0:3]=[CH;+0:4]-[*:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Delta3,5-delta2,4-dienoyl-CoA isomerase from rat liver. Molecular characterization. | Filppula SA, Yagi AI, Kilpeläinen SH, Novikov D, FitzPatrick DR, Vihinen M, Valle D, Hiltunen JK | 1998 Jan 2 | 9417087 |
| The isomerase and hydratase reaction mechanism of the crotonase active site of the multifunctional enzyme (type-1), as deduced from structures of complexes with 3S-hydroxy-acyl-CoA. | Kasaragod P, Schmitz W, Hiltunen JK, Wierenga RK | 2013 Jul | 23351063 |
| Peroxisomal bifunctional protein from rat liver is a trifunctional enzyme possessing 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and delta 3, delta 2-enoyl-CoA isomerase activities. | Palosaari PM, Hiltunen JK | 1990 Feb 15 | 2303409 |
| Organization of the multifunctional enzyme type 1: interaction between N- and C-terminal domains is required for the hydratase-1/isomerase activity. | Kiema TR, Taskinen JP, Pirilä PL, Koivuranta KT, Wierenga RK, Hiltunen JK | 2002 Oct 15 | 12106015 |
| RHEA:23716 | (3Z)-dodecenoyl-CoA = (2E)-dodecenoyl-CoA |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3]=[CH;+0:4]-[*:5]>>[*:1]-[CH;+0:2]=[CH;+0:3]-[CH2;+0:4]-[*:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and properties of 3-cis-2-trans-enoyl-CoA isomerase (dodecenoyl-CoA delta-isomerase) from rat liver mitochondria. | Stoffel W, Grol M | 1978 Dec | 738702 |
| [The metabolism of unsaturated fatty acid. 3. On the beta-oxidation of mono- and polyene-fatty acids. The mechanism of the enzymatic reaction on delta-3-cis-enoyl-CoA compounds]. | Stoffel W, Ditzer R, Caesar H | 1964 | 5830064 |
| Purification of hog liver isomerase. Mechanism of isomerization of 3-alkenyl and 3-alkynyl thioesters. | Miesowicz FM, Bloch K | 1979 Jul 10 | 376522 |