EC number:5.3.99.2

Enzyme

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     5. Isomerases
        5.3 Intramolecular oxidoreductases
            5.3.99 Other intramolecular oxidoreductases
ID:5.3.99.2
Description:Prostaglandin-D synthase.
Alternative Name: Prostaglandin-H(2) Delta-isomerase.
Prostaglandin endoperoxide Delta-isomerase.
Prostaglandin D2 synthase.
Prostaglandin D synthetase.
PGH-PGD isomerase.
PGD2 synthase.
Prosite: PDOC00187;
PDB:
PDBScop
2RD7 8049572; 8052045; 8028897; 8041276;
3OJY 8049572; 8049573; 8052045; 8052046; 8052128; 8052129; 8052130; 8052131; 8052136; 8052137; 8052138; 8052139; 8052143; 8052144; 8052145; 8052146; 8052147; 8052148; 8052149; 8052150; 8028897; 8041276;
6H04 8049565; 8052039; 8052124; 8052125; 8052126; 8052127; 8052140; 8052141; 8049565; 8052039; 8052124; 8052125; 8052126; 8052127; 8052140; 8052141; 8049565; 8052039; 8052124; 8052125; 8052126; 8052127; 8052140; 8052141; 8049565; 8052039; 8052124; 8052125; 8052126; 8052127; 8052140; 8052141; 8049565; 8052039; 8052124; 8052125; 8052126; 8052127; 8052140; 8052141; 8049565; 8052039; 8052124; 8052125; 8052126; 8052127; 8052140; 8052141; 8025227; 8037606; 8028897; 8041276; 8049565; 8052039; 8052124; 8052125; 8052126; 8052127; 8052140; 8052141; 8049565; 8052039; 8052124; 8052125; 8052126; 8052127; 8052140; 8052141; 8049565; 8052039; 8052124; 8052125; 8052126; 8052127; 8052140; 8052141; 8049565; 8052039; 8052124; 8052125; 8052126; 8052127; 8052140; 8052141; 8049572; 8052045; 8052128; 8052129; 8052136; 8052137; 8052143; 8052144; 8052147; 8052148; 8049568; 8052040; 8052108; 8052109; 8052110; 8052111; 8052116; 8052117; 8052118; 8052119; 8052120; 8052121; 8052122; 8052123; 8052132; 8052133; 8049565; 8052039; 8052124; 8052125; 8052126; 8052127; 8052140; 8052141; 8049565; 8052039; 8052124; 8052125; 8052126; 8052127; 8052140; 8052141; 8049565; 8052039; 8052124; 8052125; 8052126; 8052127; 8052140; 8052141; 8049565; 8052039; 8052124; 8052125; 8052126; 8052127; 8052140; 8052141; 8049565; 8052039; 8052124; 8052125; 8052126; 8052127; 8052140; 8052141; 8049573; 8052046; 8052130; 8052131; 8052138; 8052139; 8052145; 8052146; 8052149; 8052150; 8049565; 8052039; 8052124; 8052125; 8052126; 8052127; 8052140; 8052141; 8049565; 8052039; 8052124; 8052125; 8052126; 8052127; 8052140; 8052141; 8049565; 8052039; 8052124; 8052125; 8052126; 8052127; 8052140; 8052141;
3CQR 8049105; 8052645; 8049105; 8052645;
3CQN 8049105; 8052645; 8049105; 8052645;
 » show all
Cath: 1.20.1050.10; 2.40.128.20; 3.40.30.10;

3D structure

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PDB

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2RD7; 3OJY; 6H04; 3CQR; 3CQN; 1BBP; 1N0S; 1T0V; 1LNM; 1LKE; 1KXO; 2A2U; 2A2G; 2NNE; 2NND; 1MUP; 1I06; 1I05; 1I04; 1EPB; 1EPA; 1EXS; 6NKQ; 6FXB; 2AKQ; 5Y5C; 3PH6; 3PH5; 2R56; 2Q39; 1BEB; 6QPE; 6QPD; 6QI7; 6QI6; 6GHH; 6GFS; 6GF9; 6GE7; 5NUN; 5NUM; 5NUK; 5NUJ; 5LKF; 5LKE; 5K06; 5IO7; 5IO5; 5HTE; 5HTD; 4Y0R; 4Y0P; 4LZV; 4LZU; 4KII; 4IBA; 4IB9; 4IB8; 4IB7; 4IB6; 4GNY; 4DQ4; 4DQ3; 3UEX; 3UEW; 3UEV; 3UEU; 3NQ9; 3NQ3; 3NPO; 3BLG; 2Q2P; 2Q2M; 2GJ5; 1UZ2; 1QG5; 1GXA; 1GX9; 1GX8; 1DV9; 1CJ5; 1BSY; 1BSQ; 1BSO; 1B8E; 1B0O; 1EW3; 4O9S; 3FMZ; 2WQA; 5NUB; 5NUA; 5NU9; 5NU8; 5NU7; 5NU6; 5NU2; 5NTY; 2WR6; 2WQ9; 1JYJ; 1JYD; 1BRQ; 1BRP; 1AQB; 2QOS; 2OVE; 2OVD; 2OVA; 1LF7; 1IW2; 1RLB; 1QAB; 3BSZ; 2ACO; 1QWD; 3MBT; 1GM6; 1IIU; 1PBO; 1OBP; 1HN2; 1GT5; 1GT4; 1GT3; 1GT1; 1G85; 1Z24; 1YUP; 4ZHH; 4ZHG; 4ZHF; 4QAE; 4MVL; 3U0D; 6GR0; 5N47; 5KID; 5KIC; 5KHP; 4ZHD; 4ZHC; 4ZFX; 4K19; 3TZS; 3TF6; 3T1D; 3PED; 3PEC; 3K3L; 3I0A; 3HWG; 3HWF; 3HWE; 3HWD; 3FW5; 3FW4; 3DTQ; 3CMP; 3CBC; 3BY0; 1X8U; 1X89; 1X71; 1L6M; 6GQZ; 5N48; 5JR8; 4GH7; 3DSZ; 1DFV; 5NKN; 5MHH; 4MVK; 4MVI; 4IAX; 1QQS; 1NGL; 1KT7; 1KT6; 1KT5; 1KT4; 1KT3; 1HBQ; 1HBP; 1FEN; 1FEL; 1ERB; 2LBV; 2KT4; 1JZU; 5X7Y; 5WY9; 5EEE; 5EED; 4Y0S; 4Y0Q; 4TLJ; 4R0B; 4PSQ; 4OS8; 4OS3; 4OS0; 4ORY; 4ORX; 4ORW; 4ORU; 4ORS; 4ORR; 4OMX; 4OMW; 4NLJ; 4NLI; 4IMO; 4IMN; 4IAW; 4ES7; 4CK4; 3U9P; 3U03; 3S26; 3QKG; 3O2Y; 3O22; 3O19; 3L4R; 3KZA; 3KFI; 3KFH; 3KFG; 3KFF; 3FIQ; 2XST; 2WWP; 2RQ0; 2OZQ; 2LB6; 2L9C; 2KTD; 2E4J; 2DM5; 2BLG; 1ZNL; 1ZNK; 1ZNH; 1ZNG; 1ZNE; 1ZND; 1YP7; 1YP6; 1RBP; 1QY2; 1QY1; 1QY0; 1JV4; 1GKA; 1FEM; 1DF3;

References

External Links

UniProtKB Enzyme Link: UniProtKB 5.3.99.2
BRENDA Enzyme Link: BRENDA 5.3.99.2
KEGG Enzyme Link: KEGG5.3.99.2
BioCyc Enzyme Link: BioCyc 5.3.99.2
ExPASy Enzyme Link: ExPASy5.3.99.2
EC2PDB Enzyme Link: EC2PDB 5.3.99.2
ExplorEnz Enzyme Link: ExplorEnz 5.3.99.2
PRIAM enzyme-specific profiles Link: PRIAM 5.3.99.2
IntEnz Enzyme Link: IntEnz 5.3.99.2
MEDLINE Enzyme Link: MEDLINE 5.3.99.2

EC number:5.3.99.2

MSA:

5.3.99.2;
Phylogenetic Tree:

5.3.99.2;
Uniprot:
M-CSA:
RHEA:10600 prostaglandin H2 = prostaglandin D2
RULE(radius=1) [*:1]-[CH;+0:2]1-[*:3]-[*:4]-[O;H0;+0:5]-[O;H0;+0:6]-1>>[*:1]-[C;H0;+0:2](=[O;H0;+0:6])-[*:3]-[*:4]-[OH;+0:5]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Sequence, catalytic properties and expression of chicken glutathione-dependent prostaglandin D2 synthase, a novel class Sigma glutathione S-transferase.Thomson AM, Meyer DJ, Hayes JD1998 Jul 159657971
Identification of a fertility-associated protein in bull seminal plasma as lipocalin-type prostaglandin D synthase.Gerena RL, Irikura D, Urade Y, Eguchi N, Chapman DA, Killian GJ1998 Mar9510973
Structure-function analysis of human l-prostaglandin D synthase bound with fatty acid molecules.Zhou Y, Shaw N, Li Y, Zhao Y, Zhang R, Liu ZJ2010 Dec20667974
Structural basis of the catalytic mechanism operating in open-closed conformers of lipocalin type prostaglandin D synthase.Kumasaka T, Aritake K, Ago H, Irikura D, Tsurumura T, Yamamoto M, Miyano M, Urade Y, Hayaishi O2009 Aug 1419546224
NMR solution structure of lipocalin-type prostaglandin D synthase: evidence for partial overlapping of catalytic pocket and retinoic acid-binding pocket within the central cavity.Shimamoto S, Yoshida T, Inui T, Gohda K, Kobayashi Y, Fujimori K, Tsurumura T, Aritake K, Urade Y, Ohkubo T2007 Oct 2617715133
Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides.Kozak KR, Crews BC, Morrow JD, Wang LH, Ma YH, Weinander R, Jakobsson PJ, Marnett LJ2002 Nov 2212244105
Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Conservation of the ancestral genomic structure of sigma-class glutathione S-transferase.Kanaoka Y, Fujimori K, Kikuno R, Sakaguchi Y, Urade Y, Hayaishi O2000 Jun10824118