Enzyme

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     5. Isomerases
        5.3 Intramolecular oxidoreductases
            5.3.99 Other intramolecular oxidoreductases
ID:5.3.99.3
Description:Prostaglandin-E synthase.
Alternative Name: Prostaglandin-H(2) E-isomerase.
PGH-PGE isomerase.
PGE isomerase.
Endoperoxide isomerase.
Cath: 1.20.1050.10; 1.20.120.550; 4.10.80.80; 3.40.30.10; 2.60.40.790;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 5.3.99.3
BRENDA Enzyme Link: BRENDA 5.3.99.3
KEGG Enzyme Link: KEGG5.3.99.3
BioCyc Enzyme Link: BioCyc 5.3.99.3
ExPASy Enzyme Link: ExPASy5.3.99.3
EC2PDB Enzyme Link: EC2PDB 5.3.99.3
ExplorEnz Enzyme Link: ExplorEnz 5.3.99.3
PRIAM enzyme-specific profiles Link: PRIAM 5.3.99.3
IntEnz Enzyme Link: IntEnz 5.3.99.3
MEDLINE Enzyme Link: MEDLINE 5.3.99.3
MSA:

5.3.99.3;

Phylogenetic Tree:

5.3.99.3;

Uniprot:
M-CSA:
RHEA:12893 prostaglandin H2 = prostaglandin E2
RULE(radius=1) [*:1]-[CH;+0:2]1-[*:3]-[*:4]-[O;H0;+0:5]-[O;H0;+0:6]-1>>[*:1]-[C;H0;+0:2](=[O;H0;+0:6])-[*:3]-[*:4]-[OH;+0:5]
Reaction
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References

TitleAuthorsDatePubMed ID
Studies on membrane-associated prostaglandin E synthase-2 with reference to production of 12L-hydroxy-5,8,10-heptadecatrienoic acid (HHT).Watanabe K, Ito S, Yamamoto S2008 Mar 2118198127
Structural and functional characterization of human microsomal prostaglandin E synthase-1 by computational modeling and site-directed mutagenesis.Huang X, Yan W, Gao D, Tong M, Tai HH, Zhan CG2006 May 1516439136
Essential 110Cys in active site of membrane-associated prostaglandin E synthase-2.Watanabe K, Ohkubo H, Niwa H, Tanikawa N, Koda N, Ito S, Ohmiya Y2003 Jun 2712804604
Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination.Thorén S, Weinander R, Saha S, Jegerschöld C, Pettersson PL, Samuelsson B, Hebert H, Hamberg M, Morgenstern R, Jakobsson PJ2003 Jun 2012672824
Purification and characterization of recombinant microsomal prostaglandin E synthase-1.Ouellet M, Falgueyret JP, Ear PH, Pen A, Mancini JA, Riendeau D, Percival MD2002 Dec12460774
Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides.Kozak KR, Crews BC, Morrow JD, Wang LH, Ma YH, Weinander R, Jakobsson PJ, Marnett LJ2002 Nov 2212244105
Identification and characterization of a novel type of membrane-associated prostaglandin E synthase.Tanikawa N, Ohmiya Y, Ohkubo H, Hashimoto K, Kangawa K, Kojima M, Ito S, Watanabe K2002 Mar 811866447
Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis.Tanioka T, Nakatani Y, Semmyo N, Murakami M, Kudo I2000 Oct 2010922363
Purification and characterization of membrane-bound prostaglandin E synthase from bovine heart.Watanabe K, Kurihara K, Suzuki T1999 Aug 1810446427
Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target.Jakobsson PJ, Thorén S, Morgenstern R, Samuelsson B1999 Jun 2210377395