EC number:5.3.99.4
Enzyme
Download| EC Tree |
| 5. Isomerases |
| 5.3 Intramolecular oxidoreductases |
| 5.3.99 Other intramolecular oxidoreductases |
| ID: | 5.3.99.4 | ||
|---|---|---|---|
| Description: | Prostaglandin-I synthase. | ||
| Alternative Name: |
Prostacyclin synthase. PGI(2) synthetase. PGI(2) synthase. | ||
| Prosite: | PDOC00081; | ||
| PDB: |
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| Cath: | 1.10.630.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 5.3.99.4 |
| BRENDA Enzyme Link: | BRENDA 5.3.99.4 |
| KEGG Enzyme Link: | KEGG5.3.99.4 |
| BioCyc Enzyme Link: | BioCyc 5.3.99.4 |
| ExPASy Enzyme Link: | ExPASy5.3.99.4 |
| EC2PDB Enzyme Link: | EC2PDB 5.3.99.4 |
| ExplorEnz Enzyme Link: | ExplorEnz 5.3.99.4 |
| PRIAM enzyme-specific profiles Link: | PRIAM 5.3.99.4 |
| IntEnz Enzyme Link: | IntEnz 5.3.99.4 |
| MEDLINE Enzyme Link: | MEDLINE 5.3.99.4 |
| RHEA:23580 | prostaglandin H2 = prostaglandin I2 |
| RULE(radius=1) | ([*:1]-[O;H0;+0:2]-[O;H0;+0:3]-[*:4].[*:5]=[CH;+0:6]-[*:7])>>([*:1]-[O;H0;+0:2]-[C;H0;+0:6](=[*:5])-[*:7].[*:4]-[OH;+0:3]) |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Prostacyclin and thromboxane synthases. | Tanabe T, Ullrich V | 1995 Oct | 8777569 |
| Spectral evidence for the cytochrome P450 nature of prostacyclin synthetase. | Ullrich V, Castle L, Weber P | 1981 Jul 15 | 7023490 |
| Purification of prostacyclin synthase from bovine aorta by immunoaffinity chromatography. Evidence that the enzyme is a hemoprotein. | DeWitt DL, Smith WL | 1983 Mar 10 | 6338016 |
| Peroxidase-dependent deactivation of prostacyclin synthetase. | Ham EA, Egan RW, Soderman DD, Gale PH, Kuehl FA Jr | 1979 Apr 10 | 372178 |
| Analysis of genetic polymorphism and biochemical characterization of a functionally decreased variant in prostacyclin synthase gene (CYP8A1) in humans. | Cho SA, Rohn-Glowacki KJ, Jarrar YB, Yi M, Kim WY, Shin JG, Lee SJ | 2015 Mar 1 | 25623425 |
| Structures of prostacyclin synthase and its complexes with substrate analog and inhibitor reveal a ligand-specific heme conformation change. | Li YC, Chiang CW, Yeh HC, Hsu PY, Whitby FG, Wang LH, Chan NL | 2008 Feb 1 | 18032380 |
| Purification and characterization of recombinant human prostacyclin synthase. | Wada M, Yokoyama C, Hatae T, Shimonishi M, Nakamura M, Imai Y, Ullrich V, Tanabe T | 2004 Apr | 15115769 |