EC number:5.3.99.5
Enzyme
Download| EC Tree |
| 5. Isomerases |
| 5.3 Intramolecular oxidoreductases |
| 5.3.99 Other intramolecular oxidoreductases |
| ID: | 5.3.99.5 | ||
|---|---|---|---|
| Description: | Thromboxane-A synthase. | ||
| Alternative Name: |
Thromboxane synthetase. Thromboxane synthase. | ||
| Prosite: | PDOC00081; | ||
| PDB: |
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3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 5.3.99.5 |
| BRENDA Enzyme Link: | BRENDA 5.3.99.5 |
| KEGG Enzyme Link: | KEGG5.3.99.5 |
| BioCyc Enzyme Link: | BioCyc 5.3.99.5 |
| ExPASy Enzyme Link: | ExPASy5.3.99.5 |
| EC2PDB Enzyme Link: | EC2PDB 5.3.99.5 |
| ExplorEnz Enzyme Link: | ExplorEnz 5.3.99.5 |
| PRIAM enzyme-specific profiles Link: | PRIAM 5.3.99.5 |
| IntEnz Enzyme Link: | IntEnz 5.3.99.5 |
| MEDLINE Enzyme Link: | MEDLINE 5.3.99.5 |
| RHEA:17137 | prostaglandin H2 = thromboxane A2 |
| RULE(radius=1) | [*:1]-[CH;+0:2]1-[*:3]-[*:4]2-[*:5]-[CH;+0:6]-1-[O;H0;+0:7]-[O;H0;+0:8]-2>>[*:1]-[CH;+0:2]1-[*:3]-[*:4]2-[*:5]-[CH;+0:6](-[O;H0;+0:8]-2)-[O;H0;+0:7]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Expression of human thromboxane synthase using a baculovirus system. | Yokoyama C, Miyata A, Suzuki K, Nishikawa Y, Yoshimoto T, Yamamoto S, Nüsing R, Ullrich V, Tanabe T | 1993 Feb 22 | 8436233 |
| Thromboxane synthase as a cytochrome P450 enzyme. | Ullrich V, Haurand M | 1983 | 6221511 |
| Thromboxane synthase catalyses hydroxylations of prostaglandin H2 analogs in the presence of iodosylbenzene. | Hecker M, Baader WJ, Weber P, Ullrich V | 1987 Dec 15 | 3691505 |
| Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand. | Matsunobu T, Okuno T, Yokoyama C, Yokomizo T | 2013 Nov | 24009185 |
| Substrate binding is the rate-limiting step in thromboxane synthase catalysis. | Wang LH, Tsai AL, Hsu PY | 2001 May 4 | 11297515 |