EC number:5.4.2.9
Enzyme
Download| EC Tree |
| 5. Isomerases |
| 5.4 Intramolecular transferases |
| 5.4.2 Phosphotransferases (phosphomutases) |
| ID: | 5.4.2.9 |
|---|---|
| Description: | Phosphoenolpyruvate mutase. |
| Alternative Name: |
Phosphoenolpyruvate phosphomutase. PEP phosphomutase. PEP mutase. |
| Cath: | 3.20.20.60; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 5.4.2.9 |
| BRENDA Enzyme Link: | BRENDA 5.4.2.9 |
| KEGG Enzyme Link: | KEGG5.4.2.9 |
| BioCyc Enzyme Link: | BioCyc 5.4.2.9 |
| ExPASy Enzyme Link: | ExPASy5.4.2.9 |
| EC2PDB Enzyme Link: | EC2PDB 5.4.2.9 |
| ExplorEnz Enzyme Link: | ExplorEnz 5.4.2.9 |
| PRIAM enzyme-specific profiles Link: | PRIAM 5.4.2.9 |
| IntEnz Enzyme Link: | IntEnz 5.4.2.9 |
| MEDLINE Enzyme Link: | MEDLINE 5.4.2.9 |
| RHEA:17013 | H(+) + phosphoenolpyruvate = 3-phosphonopyruvate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[CH2;+0:3])-[O;H0;+0:4]-[P;H0;+0:5](=[*:6])(-[*:7])-[*:8].[H+;H0:9]>>[*:1]-[C;H0;+0:2](=[O;H0;+0:4])-[CH2;+0:3]-[P;H0;+0:5](=[*:6])(-[*:7])-[*:8] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Interaction of inhibitors with phosphoenolpyruvate mutase: implications for the reaction mechanism and the nature of the active site. | Seidel HM, Knowles JR | 1994 May 10 | 8180189 |
| Purification and characterization of the Tetrahymena pyriformis P-C bond forming enzyme phosphoenolpyruvate phosphomutase. | Bowman ED, McQueney MS, Scholten JD, Dunaway-Mariano D | 1990 Jul 31 | 2121271 |
| Dissociative phosphoryl transfer in PEP mutase catalysis: structure of the enzyme/sulfopyruvate complex and kinetic properties of mutants. | Liu S, Lu Z, Jia Y, Dunaway-Mariano D, Herzberg O | 2002 Aug 13 | 12162742 |
| Insight into the mechanism of phosphoenolpyruvate mutase catalysis derived from site-directed mutagenesis studies of active site residues. | Jia Y, Lu Z, Huang K, Herzberg O, Dunaway-Mariano D | 1999 Oct 26 | 10571990 |
| Helix swapping between two alpha/beta barrels: crystal structure of phosphoenolpyruvate mutase with bound Mg(2+)-oxalate. | Huang K, Li Z, Jia Y, Dunaway-Mariano D, Herzberg O | 1999 May | 10378273 |