EC number:5.4.3.3
Enzyme
Download| EC Tree |
| 5. Isomerases |
| 5.4 Intramolecular transferases |
| 5.4.3 Transferring amino groups |
| ID: | 5.4.3.3 |
|---|---|
| Description: | Lysine 5,6-aminomutase. |
| Alternative Name: |
D-lysine 5,6-aminomutase. Beta-lysine mutase. Beta-lysine 5,6-aminomutase. Adenosylcobalamin-dependent D-lysine 5,6-aminomutase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 5.4.3.3 |
| BRENDA Enzyme Link: | BRENDA 5.4.3.3 |
| KEGG Enzyme Link: | KEGG5.4.3.3 |
| BioCyc Enzyme Link: | BioCyc 5.4.3.3 |
| ExPASy Enzyme Link: | ExPASy5.4.3.3 |
| EC2PDB Enzyme Link: | EC2PDB 5.4.3.3 |
| ExplorEnz Enzyme Link: | ExplorEnz 5.4.3.3 |
| PRIAM enzyme-specific profiles Link: | PRIAM 5.4.3.3 |
| IntEnz Enzyme Link: | IntEnz 5.4.3.3 |
| MEDLINE Enzyme Link: | MEDLINE 5.4.3.3 |
| RHEA:21736 | (3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[NH2;+0:4]>>[*:1]-[CH;+0:2](-[CH3;+0:3])-[NH2;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Pathway of lysine degradation in Fusobacterium nucleatum. | Barker HA, Kahn JM, Hedrick L | 1982 Oct | 6811551 |
| Large-scale domain motions and pyridoxal-5'-phosphate assisted radical catalysis in coenzyme B12-dependent aminomutases. | Maity AN, Chen YH, Ke SC | 2014 Feb 20 | 24562332 |
| Radical stabilization is crucial in the mechanism of action of lysine 5,6-aminomutase: role of tyrosine-263α as revealed by electron paramagnetic resonance spectroscopy. | Chen YH, Maity AN, Pan YC, Frey PA, Ke SC | 2011 Nov 2 | 21939264 |
| RHEA:18241 | D-lysine = (2R,5S)-2,5-diaminohexanoate |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH2;+0:3]-[NH2;+0:4]>>[*:1]-[CH;+0:2](-[CH3;+0:3])-[NH2;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Radical triplets and suicide inhibition in reactions of 4-thia-D- and 4-thia-L-lysine with lysine 5,6-aminomutase. | Tang KH, Mansoorabadi SO, Reed GH, Frey PA | 2009 Sep 1 | 19634897 |
| Identification of a novel pyridoxal 5'-phosphate binding site in adenosylcobalamin-dependent lysine 5,6-aminomutase from Porphyromonas gingivalis. | Tang KH, Harms A, Frey PA | 2002 Jul 9 | 12093296 |