EC number:5.4.4.5

Enzyme

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     5. Isomerases
        5.4 Intramolecular transferases
            5.4.4 Transferring hydroxy groups
ID:5.4.4.5
Description:9,12-octadecadienoate 8-hydroperoxide 8R-isomerase.
Alternative Name: 5,8-dihydroxy-9,12-octadecadienoate-forming).
(8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((5S,8R,9Z,12Z)-

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 5.4.4.5
BRENDA Enzyme Link: BRENDA 5.4.4.5
KEGG Enzyme Link: KEGG5.4.4.5
BioCyc Enzyme Link: BioCyc 5.4.4.5
ExPASy Enzyme Link: ExPASy5.4.4.5
EC2PDB Enzyme Link: EC2PDB 5.4.4.5
ExplorEnz Enzyme Link: ExplorEnz 5.4.4.5
PRIAM enzyme-specific profiles Link: PRIAM 5.4.4.5
IntEnz Enzyme Link: IntEnz 5.4.4.5
MEDLINE Enzyme Link: MEDLINE 5.4.4.5

EC number:5.4.4.5

MSA:

5.4.4.5;
Phylogenetic Tree:

5.4.4.5;
Uniprot:
M-CSA:
RHEA:31579 (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate
RULE(radius=1) ([*:1]-[CH2;+0:2]-[*:3].[*:4]-[O;H0;+0:5]-[OH;+0:6])>>([*:1]-[CH;+0:2](-[*:3])-[OH;+0:6].[*:4]-[OH;+0:5])
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Expression of 5,8-LDS of Aspergillus fumigatus and its dioxygenase domain. A comparison with 7,8-LDS, 10-dioxygenase, and cyclooxygenase.Hoffmann I, Jernerén F, Garscha U, Oliw EH2011 Feb 1521130068
Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus.Jernerén F, Garscha U, Hoffmann I, Hamberg M, Oliw EH2010 Apr20045744
Identification of PpoA from Aspergillus nidulans as a fusion protein of a fatty acid heme dioxygenase/peroxidase and a cytochrome P450.Brodhun F, Göbel C, Hornung E, Feussner I2009 May 119286665