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5. Isomerases

5.4 Intramolecular transferases

5.4.99 Transferring other groups

ID:

5.4.99.17

Description:

Squalene--hopene cyclase.

Prosite:

PDOC00825;

PDB:

PDB	Scop

Cath:

1.50.10.20;

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UniProtKB Enzyme Link:	UniProtKB 5.4.99.17
BRENDA Enzyme Link:	BRENDA 5.4.99.17
KEGG Enzyme Link:	KEGG5.4.99.17
BioCyc Enzyme Link:	BioCyc 5.4.99.17
ExPASy Enzyme Link:	ExPASy5.4.99.17
EC2PDB Enzyme Link:	EC2PDB 5.4.99.17
ExplorEnz Enzyme Link:	ExplorEnz 5.4.99.17
PRIAM enzyme-specific profiles Link:	PRIAM 5.4.99.17
IntEnz Enzyme Link:	IntEnz 5.4.99.17
MEDLINE Enzyme Link:	MEDLINE 5.4.99.17

RHEA:17637	squalene = hop-22(29)-ene
RULE(radius=1)	[:1]-[C;H0;+0:2](-[:3]-[:4]-[CH;+0:5]=[C;H0;+0:6](-[:7])-[:8]-[:9]-[CH;+0:10]=[C;H0;+0:11](-[:12])-[:13])=[CH;+0:14]-[:15]-[:16]-[CH;+0:17]=[C;H0;+0:18](-[:19])-[:20]-[:21]-[CH;+0:22]=[C;H0;+0:23](-[:24])-[:25]-[:26]-[CH;+0:27]=[C;H0;+0:28](-[:29])-[CH3;+0:30]>>[:1]-[C;H0;+0:2]12-[:3]-[:4]-[CH;+0:5]3-[C;H0;+0:6](-[:7])(-[:8]-[:9]-[CH2;+0:10]-[C;H0;+0:11]-3(-[:12])-[:13])-[CH;+0:14]-1-[:15]-[:16]-[CH;+0:17]1-[C;H0;+0:18]-2(-[:19])-[:20]-[:21]-[CH;+0:22]2-[CH;+0:27](-[C;H0;+0:28](-[:29])=[CH2;+0:30])-[:26]-[:25]-[C;H0;+0:23]-1-2-[:24]
Reaction
Core-to-Core	No scaffolds atoms were exchanged as a result of the reaction

Title	Authors	Date	PubMed ID
The structure of the membrane protein squalene-hopene cyclase at 2.0 A resolution.	Wendt KU, Lenhart A, Schulz GE	1999 Feb 12	9931258
Squalene hopene cyclases: highly promiscuous and evolvable catalysts for stereoselective CC and CX bond formation.	Hammer SC, Syrén PO, Seitz M, Nestl BM, Hauer B	2013 Apr	23485581
Squalene-hopene cyclases.	Siedenburg G, Jendrossek D	2011 Jun	21531832