EC number:5.4.99.18
Enzyme
Download| EC Tree |
| 5. Isomerases |
| 5.4 Intramolecular transferases |
| 5.4.99 Transferring other groups |
| ID: | 5.4.99.18 |
|---|---|
| Description: | 5-(carboxyamino)imidazole ribonucleotide mutase. |
| Alternative Name: |
N(5)-carboxyaminoimidazole ribonucleotide mutase. N(5)-CAIR mutase. |
| Cath: | 3.30.1490.20; 3.30.470.20; 3.40.50.7700; 3.40.50.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 5.4.99.18 |
| BRENDA Enzyme Link: | BRENDA 5.4.99.18 |
| KEGG Enzyme Link: | KEGG5.4.99.18 |
| BioCyc Enzyme Link: | BioCyc 5.4.99.18 |
| ExPASy Enzyme Link: | ExPASy5.4.99.18 |
| EC2PDB Enzyme Link: | EC2PDB 5.4.99.18 |
| ExplorEnz Enzyme Link: | ExplorEnz 5.4.99.18 |
| PRIAM enzyme-specific profiles Link: | PRIAM 5.4.99.18 |
| IntEnz Enzyme Link: | IntEnz 5.4.99.18 |
| MEDLINE Enzyme Link: | MEDLINE 5.4.99.18 |
EC number:5.4.99.18
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:13193 | 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[*:3])-[NH;+0:4]-[*:5]:[cH;+0:6]:[*:7].[H+;H0:8]>>[*:1]=[C;H0;+0:2](-[*:3])-[c;H0;+0:6](:[*:7]):[*:5]-[NH2;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway. | Meyer E, Leonard NJ, Bhat B, Stubbe J, Smith JM | 1992 Jun 2 | 1534690 |
| Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway. | Mathews II, Kappock TJ, Stubbe J, Ealick SE | 1999 Nov 15 | 10574791 |
| Evidence for the direct transfer of the carboxylate of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to generate 4-carboxy-5-aminoimidazole ribonucleotide catalyzed by Escherichia coli PurE, an N5-CAIR mutase. | Meyer E, Kappock TJ, Osuji C, Stubbe J | 1999 Mar 9 | 10074353 |