EC number:5.4.99.28
Enzyme
Download| EC Tree |
| 5. Isomerases |
| 5.4 Intramolecular transferases |
| 5.4.99 Transferring other groups |
| ID: | 5.4.99.28 |
|---|---|
| Description: | tRNA pseudouridine(32) synthase. |
| Alternative Name: |
Pseudouridine synthase RluA. |
| Cath: | 3.30.2350.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 5.4.99.28 |
| BRENDA Enzyme Link: | BRENDA 5.4.99.28 |
| KEGG Enzyme Link: | KEGG5.4.99.28 |
| BioCyc Enzyme Link: | BioCyc 5.4.99.28 |
| ExPASy Enzyme Link: | ExPASy5.4.99.28 |
| EC2PDB Enzyme Link: | EC2PDB 5.4.99.28 |
| ExplorEnz Enzyme Link: | ExplorEnz 5.4.99.28 |
| PRIAM enzyme-specific profiles Link: | PRIAM 5.4.99.28 |
| IntEnz Enzyme Link: | IntEnz 5.4.99.28 |
| MEDLINE Enzyme Link: | MEDLINE 5.4.99.28 |
EC number:5.4.99.28
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:42544 | uridine(32) in tRNA = pseudouridine(32) in tRNA |
| RULE(radius=1) | [*:1]:[cH;+0:2]:[*:3]:[n;H0;+0:4](:[*:5])-[CH;+0:6](-[*:7])-[*:8]>>[*:1]:[c;H0;+0:2](:[*:3]:[nH;+0:4]:[*:5])-[CH;+0:6](-[*:7])-[*:8] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A dual-specificity pseudouridine synthase: an Escherichia coli synthase purified and cloned on the basis of its specificity for psi 746 in 23S RNA is also specific for psi 32 in tRNA(phe). | Wrzesinski J, Nurse K, Bakin A, Lane BG, Ofengand J | 1995 Jun | 7493321 |
| Crystal structure of pseudouridine synthase RluA: indirect sequence readout through protein-induced RNA structure. | Hoang C, Chen J, Vizthum CA, Kandel JM, Hamilton CS, Mueller EG, Ferré-D'Amaré AR | 2006 Nov 17 | 17188032 |
| Pseudouridylation at position 32 of mitochondrial and cytoplasmic tRNAs requires two distinct enzymes in Saccharomyces cerevisiae. | Behm-Ansmant I, Grosjean H, Massenet S, Motorin Y, Branlant C | 2004 Dec 17 | 15466869 |