EC number:5.4.99.41
Enzyme
Download| EC Tree |
| 5. Isomerases |
| 5.4 Intramolecular transferases |
| 5.4.99 Transferring other groups |
| ID: | 5.4.99.41 |
|---|---|
| Description: | Lupeol synthase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 5.4.99.41 |
| BRENDA Enzyme Link: | BRENDA 5.4.99.41 |
| KEGG Enzyme Link: | KEGG5.4.99.41 |
| BioCyc Enzyme Link: | BioCyc 5.4.99.41 |
| ExPASy Enzyme Link: | ExPASy5.4.99.41 |
| EC2PDB Enzyme Link: | EC2PDB 5.4.99.41 |
| ExplorEnz Enzyme Link: | ExplorEnz 5.4.99.41 |
| PRIAM enzyme-specific profiles Link: | PRIAM 5.4.99.41 |
| IntEnz Enzyme Link: | IntEnz 5.4.99.41 |
| MEDLINE Enzyme Link: | MEDLINE 5.4.99.41 |
EC number:5.4.99.41
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:31383 | (S)-2,3-epoxysqualene = lupeol |
| RULE(radius=1) | ([*:1]-[C;H0;+0:2](-[*:3]-[*:4]-[CH;+0:5]=[C;H0;+0:6](-[CH3;+0:7])-[CH3;+0:8])=[CH;+0:9]-[*:10]-[CH2;+0:11]-[C;H0;+0:12](-[CH3;+0:13])=[CH;+0:14]-[*:15]-[*:16]-[CH;+0:17]=[C;H0;+0:18](-[*:19])-[*:20]-[*:21]-[CH;+0:22]=[C;H0;+0:23](-[*:24])-[*:25].[*:26]-[C;H0;+0:27]1(-[*:28])-[*:29]-[O;H0;+0:30]-1)>>[*:1]-[C;H0;+0:2]12-[*:3]-[*:4]-[C;H0;+0:5]3(-[CH3;+0:6])-[CH;+0:14](-[*:15]-[*:16]-[CH;+0:17]4-[C;H0;+0:23](-[*:24])(-[*:25])-[CH;+0:22](-[C;H0;+0:27](-[*:26])(-[*:28])-[*:29]-[OH;+0:30])-[*:21]-[*:20]-[C;H0;+0:18]-4-3-[*:19])-[CH;+0:12]-1-[CH;+0:11](-[C;H0;+0:8](=[CH2;+0:7])-[CH3;+0:13])-[*:10]-[CH2;+0:9]-2 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning and characterization of the Arabidopsis thaliana lupeol synthase gene. | Herrera JB, Bartel B, Wilson WK, Matsuda SP | 1998 Dec | 9883589 |
| Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae. | Basyuni M, Oku H, Tsujimoto E, Kinjo K, Baba S, Takara K | 2007 Oct | 17803686 |
| Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra. | Hayashi H, Huang P, Takada S, Obinata M, Inoue K, Shibuya M, Ebizuka Y | 2004 Jul | 15256745 |
| Molecular cloning and expression in yeast of 2,3-oxidosqualene-triterpenoid cyclases from Arabidopsis thaliana. | Husselstein-Muller T, Schaller H, Benveniste P | 2001 Jan | 11247608 |
| Arabidopsis thaliana LUP1 converts oxidosqualene to multiple triterpene alcohols and a triterpene diol. | Segura MJ, Meyer MM, Matsuda SP | 2000 Jul 27 | 10930257 |
| Two branches of the lupeol synthase gene in the molecular evolution of plant oxidosqualene cyclases. | Shibuya M, Zhang H, Endo A, Shishikura K, Kushiro T, Ebizuka Y | 1999 Nov | 10542078 |
| Cloning and characterization of oxidosqualene cyclases from Kalanchoe daigremontiana: enzymes catalyzing up to 10 rearrangement steps yielding friedelin and other triterpenoids. | Wang Z, Yeats T, Han H, Jetter R | 2010 Sep 24 | 20610397 |
| Cloning and characterization of a lupeol synthase involved in the synthesis of epicuticular wax crystals on stem and hypocotyl surfaces of Ricinus communis. | Guhling O, Hobl B, Yeats T, Jetter R | 2006 Apr 15 | 16445885 |
| Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants. | Zhang H, Shibuya M, Yokota S, Ebizuka Y | 2003 May | 12736505 |