EC number:5.5.1.1
Enzyme
Download| EC Tree |
| 5. Isomerases |
| 5.5 Intramolecular lyases |
| 5.5.1 Intramolecular lyases (only sub-subclass identified to date) |
| ID: | 5.5.1.1 | ||
|---|---|---|---|
| Description: | Muconate cycloisomerase. | ||
| Alternative Name: |
Muconate lactonizing enzyme. Muconate cycloisomerase I. Cis,cis-muconate lactonizing enzyme I. | ||
| Prosite: | PDOC00706; | ||
| PDB: |
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| Cath: | 3.20.20.120; 3.30.390.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 5.5.1.1 |
| BRENDA Enzyme Link: | BRENDA 5.5.1.1 |
| KEGG Enzyme Link: | KEGG5.5.1.1 |
| BioCyc Enzyme Link: | BioCyc 5.5.1.1 |
| ExPASy Enzyme Link: | ExPASy5.5.1.1 |
| EC2PDB Enzyme Link: | EC2PDB 5.5.1.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 5.5.1.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 5.5.1.1 |
| IntEnz Enzyme Link: | IntEnz 5.5.1.1 |
| MEDLINE Enzyme Link: | MEDLINE 5.5.1.1 |
| RHEA:30031 | (+)-muconolactone = cis,cis-muconate + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[CH;+0:3](-[*:4])-[CH2;+0:5]-[*:6]>>([*:4]-[CH;+0:3]=[CH;+0:5]-[*:6].[*:1]-[OH;+0:2]) |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The conversion of catechol and protocatechuate to beta-ketoadipate by Pseudomonas putida. 3. Enzymes of the catechol pathway. | Ornston LN | 1966 Aug 25 | 5330966 |
| Mandelate racemase and muconate lactonizing enzyme are mechanistically distinct and structurally homologous. | Neidhart DJ, Kenyon GL, Gerlt JA, Petsko GA | 1990 Oct 18 | 2215699 |
| Insight into the reaction mechanism of cis,cis-muconate lactonizing enzymes: a DFT QM/MM study. | Somboon T, Gleeson MP, Hannongbua S | 2012 Feb | 21541743 |
| The mechanism of formation of beta-ketoadipic acid by bacteria. | SISTROM WR, STANIER RY | 1954 Oct | 13211620 |
| Evolution of enzymatic activities in the enolase superfamily: stereochemically distinct mechanisms in two families of cis,cis-muconate lactonizing enzymes. | Sakai A, Fedorov AA, Fedorov EV, Schnoes AM, Glasner ME, Brown S, Rutter ME, Bain K, Chang S, Gheyi T, Sauder JM, Burley SK, Babbitt PC, Almo SC, Gerlt JA | 2009 Feb 24 | 19220063 |