Enzyme

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     5. Isomerases
        5.5 Intramolecular lyases
            5.5.1 Intramolecular lyases (only sub-subclass identified to date)
ID:5.5.1.12
Description:Copalyl diphosphate synthase.
Cath: 1.10.600.10; 1.50.10.130; 1.50.10.160;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 5.5.1.12
BRENDA Enzyme Link: BRENDA 5.5.1.12
KEGG Enzyme Link: KEGG5.5.1.12
BioCyc Enzyme Link: BioCyc 5.5.1.12
ExPASy Enzyme Link: ExPASy5.5.1.12
EC2PDB Enzyme Link: EC2PDB 5.5.1.12
ExplorEnz Enzyme Link: ExplorEnz 5.5.1.12
PRIAM enzyme-specific profiles Link: PRIAM 5.5.1.12
IntEnz Enzyme Link: IntEnz 5.5.1.12
MEDLINE Enzyme Link: MEDLINE 5.5.1.12
MSA:

5.5.1.12;

Phylogenetic Tree:

5.5.1.12;

Uniprot:
M-CSA:
RHEA:24316 all-trans-geranylgeranyl diphosphate = (+)-copalyl diphosphate
RULE(radius=1) [*:1]-[CH;+0:2]=[C;H0;+0:3](-[CH3;+0:4])-[*:5]-[*:6]-[CH;+0:7]=[C;H0;+0:8](-[*:9])-[*:10]-[*:11]-[CH;+0:12]=[C;H0;+0:13](-[*:14])-[*:15]>>[*:1]-[CH;+0:2]1-[C;H0;+0:3](=[CH2;+0:4])-[*:5]-[*:6]-[CH;+0:7]2-[C;H0;+0:8]-1(-[*:9])-[*:10]-[*:11]-[CH2;+0:12]-[C;H0;+0:13]-2(-[*:14])-[*:15]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Evolution of conifer diterpene synthases: diterpene resin acid biosynthesis in lodgepole pine and jack pine involves monofunctional and bifunctional diterpene synthases.Hall DE, Zerbe P, Jancsik S, Quesada AL, Dullat H, Madilao LL, Yuen M, Bohlmann J2013 Feb23370714
Bifunctional cis-abienol synthase from Abies balsamea discovered by transcriptome sequencing and its implications for diterpenoid fragrance production.Zerbe P, Chiang A, Yuen M, Hamberger B, Hamberger B, Draper JA, Britton R, Bohlmann J2012 Apr 622337889
Mechanism of abietadiene synthase catalysis: stereochemistry and stabilization of the cryptic pimarenyl carbocation intermediates.Ravn MM, Peters RJ, Coates RM, Croteau R2002 Jun 1912059223
Abietadiene synthase catalysis: conserved residues involved in protonation-initiated cyclization of geranylgeranyl diphosphate to (+)-copalyl diphosphate.Peters RJ, Croteau RB2002 Feb 1211827528
Abietadiene synthase catalysis: mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement.Peters RJ, Croteau RB2002 Jan 2211805316
Bifunctional abietadiene synthase: free diffusive transfer of the (+)-copalyl diphosphate intermediate between two distinct active sites.Peters RJ, Ravn MM, Coates RM, Croteau RB2001 Sep 1911552804
Nonseed plant Selaginella moellendorffi [corrected] has both seed plant and microbial types of terpene synthases.Li G, Köllner TG, Yin Y, Jiang Y, Chen H, Xu Y, Gershenzon J, Pichersky E, Chen F2012 Sep 422908266
Enzymatic (13)C labeling and multidimensional NMR analysis of miltiradiene synthesized by bifunctional diterpene cyclase in Selaginella moellendorffii.Sugai Y, Ueno Y, Hayashi K, Oogami S, Toyomasu T, Matsumoto S, Natsume M, Nozaki H, Kawaide H2011 Dec 1622027823
Identification of diterpene biosynthetic gene clusters and functional analysis of labdane-related diterpene cyclases in Phomopsis amygdali.Toyomasu T, Niida R, Kenmoku H, Kanno Y, Miura S, Nakano C, Shiono Y, Mitsuhashi W, Toshima H, Oikawa H, Hoshino T, Dairi T, Kato N, Sassa T2008 Apr18391465
Diterpene resin acid biosynthesis in loblolly pine (Pinus taeda): functional characterization of abietadiene/levopimaradiene synthase (PtTPS-LAS) cDNA and subcellular targeting of PtTPS-LAS and abietadienol/abietadienal oxidase (PtAO, CYP720B1).Ro DK, Bohlmann J2006 Aug16497345
Functional characterization of nine Norway Spruce TPS genes and evolution of gymnosperm terpene synthases of the TPS-d subfamily.Martin DM, Fäldt J, Bohlmann J2004 Aug15310829