EC number:5.5.1.13
Enzyme
Download| EC Tree |
| 5. Isomerases |
| 5.5 Intramolecular lyases |
| 5.5.1 Intramolecular lyases (only sub-subclass identified to date) |
| ID: | 5.5.1.13 |
|---|---|
| Description: | Ent-copalyl diphosphate synthase. |
| Alternative Name: |
Ent-kaurene synthetase A. Ent-kaurene synthase A. Ent-CDP synthase. |
| Cath: | 1.10.600.10; 1.50.10.130; 1.50.10.160; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 5.5.1.13 |
| BRENDA Enzyme Link: | BRENDA 5.5.1.13 |
| KEGG Enzyme Link: | KEGG5.5.1.13 |
| BioCyc Enzyme Link: | BioCyc 5.5.1.13 |
| ExPASy Enzyme Link: | ExPASy5.5.1.13 |
| EC2PDB Enzyme Link: | EC2PDB 5.5.1.13 |
| ExplorEnz Enzyme Link: | ExplorEnz 5.5.1.13 |
| PRIAM enzyme-specific profiles Link: | PRIAM 5.5.1.13 |
| IntEnz Enzyme Link: | IntEnz 5.5.1.13 |
| MEDLINE Enzyme Link: | MEDLINE 5.5.1.13 |
| RHEA:14841 | all-trans-geranylgeranyl diphosphate = ent-copalyl diphosphate |
| RULE(radius=1) | [*:1]-[CH;+0:2]=[C;H0;+0:3](-[CH3;+0:4])-[*:5]-[*:6]-[CH;+0:7]=[C;H0;+0:8](-[*:9])-[*:10]-[*:11]-[CH;+0:12]=[C;H0;+0:13](-[*:14])-[*:15]>>[*:1]-[CH;+0:2]1-[C;H0;+0:3](=[CH2;+0:4])-[*:5]-[*:6]-[CH;+0:7]2-[C;H0;+0:8]-1(-[*:9])-[*:10]-[*:11]-[CH2;+0:12]-[C;H0;+0:13]-2(-[*:14])-[*:15] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Ent-kaurene synthase from the fungus Phaeosphaeria sp. L487. cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase in fungal gibberellin biosynthesis. | Kawaide H, Imai R, Sassa T, Kamiya Y | 1997 Aug 29 | 9268298 |
| The Arabidopsis GA1 locus encodes the cyclase ent-kaurene synthetase A of gibberellin biosynthesis. | Sun TP, Kamiya Y | 1994 Oct | 7994182 |
| A single residue switch for Mg(2+)-dependent inhibition characterizes plant class II diterpene cyclases from primary and secondary metabolism. | Mann FM, Prisic S, Davenport EK, Determan MK, Coates RM, Peters RJ | 2010 Jul 2 | 20430888 |
| Probing the role of the DXDD motif in Class II diterpene cyclases. | Prisic S, Xu J, Coates RM, Peters RJ | 2007 May 25 | 17457817 |
| Functional analysis of eubacterial ent-copalyl diphosphate synthase and pimara-9(11),15-diene synthase with unique primary sequences. | Ikeda C, Hayashi Y, Itoh N, Seto H, Dairi T | 2007 Jan | 17148547 |
| Rice contains two disparate ent-copalyl diphosphate synthases with distinct metabolic functions. | Prisic S, Xu M, Wilderman PR, Peters RJ | 2004 Dec | 15542489 |
| Cloning of a full-length cDNA encoding ent-kaurene synthase from Gibberella fujikuroi: functional analysis of a bifunctional diterpene cyclase. | Toyomasu T, Kawaide H, Ishizaki A, Shinoda S, Otsuka M, Mitsuhashi W, Sassa T | 2000 Mar | 10803977 |