EC number:5.5.1.19
Enzyme
Download| EC Tree |
| 5. Isomerases |
| 5.5 Intramolecular lyases |
| 5.5.1 Intramolecular lyases (only sub-subclass identified to date) |
| ID: | 5.5.1.19 |
|---|---|
| Description: | Lycopene beta-cyclase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 5.5.1.19 |
| BRENDA Enzyme Link: | BRENDA 5.5.1.19 |
| KEGG Enzyme Link: | KEGG5.5.1.19 |
| BioCyc Enzyme Link: | BioCyc 5.5.1.19 |
| ExPASy Enzyme Link: | ExPASy5.5.1.19 |
| EC2PDB Enzyme Link: | EC2PDB 5.5.1.19 |
| ExplorEnz Enzyme Link: | ExplorEnz 5.5.1.19 |
| PRIAM enzyme-specific profiles Link: | PRIAM 5.5.1.19 |
| IntEnz Enzyme Link: | IntEnz 5.5.1.19 |
| MEDLINE Enzyme Link: | MEDLINE 5.5.1.19 |
| RHEA:55620 | a carotenoid psi-end group = a carotenoid beta-end derivative |
| RULE(radius=1) | ([*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5].[*:6]=[CH;+0:7]-[*:8])>>[*:6]=[C;H0;+0:7](-[*:8])-[C;H0;+0:3](-[*:4])(-[*:5])-[CH2;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Functional analysis of the beta and epsilon lycopene cyclase enzymes of Arabidopsis reveals a mechanism for control of cyclic carotenoid formation. | Cunningham FX Jr, Pogson B, Sun Z, McDonald KA, DellaPenna D, Gantt E | 1996 Sep | 8837512 |
| Cloning and characterization of the cDNA for lycopene beta-cyclase from tomato reveals decrease in its expression during fruit ripening. | Pecker I, Gabbay R, Cunningham FX Jr, Hirschberg J | 1996 Feb | 8624411 |
| Molecular structure and enzymatic function of lycopene cyclase from the cyanobacterium Synechococcus sp strain PCC7942. | Cunningham FX Jr, Sun Z, Chamovitz D, Hirschberg J, Gantt E | 1994 Aug | 7919981 |
| Metabolism of cyclic carotenoids: a model for the alteration of this biosynthetic pathway in Capsicum annuum chromoplasts. | Hugueney P, Badillo A, Chen HC, Klein A, Hirschberg J, Camara B, Kuntz M | 1995 Sep | 7550379 |
| The lycopene cyclase CrtY from Pantoea ananatis (formerly Erwinia uredovora) catalyzes an FADred-dependent non-redox reaction. | Yu Q, Schaub P, Ghisla S, Al-Babili S, Krieger-Liszkay A, Beyer P | 2010 Apr 16 | 20178989 |
| Identification of a fourth family of lycopene cyclases in photosynthetic bacteria. | Maresca JA, Graham JE, Wu M, Eisen JA, Bryant DA | 2007 Jul 10 | 17606904 |
| Involvement of NADPH in the cyclization reaction of carotenoid biosynthesis. | Hornero-Méndez D, Britton G | 2002 Mar 27 | 11943208 |
| An alternative pathway to beta -carotene formation in plant chromoplasts discovered by map-based cloning of beta and old-gold color mutations in tomato. | Ronen G, Carmel-Goren L, Zamir D, Hirschberg J | 2000 Sep 26 | 10995464 |
| Cloning and functional expression in Escherichia coli of a cyanobacterial gene for lycopene cyclase, the enzyme that catalyzes the biosynthesis of beta-carotene. | Cunningham FX Jr, Chamovitz D, Misawa N, Gantt E, Hirschberg J | 1993 Aug 9 | 8344419 |
| Identification of a lycopene beta-cyclase required for bacteriorhodopsin biogenesis in the archaeon Halobacterium salinarum. | Peck RF, Johnson EA, Krebs MP | 2002 Jun | 12003928 |
| RHEA:32239 | gamma-carotene = all-trans-beta-carotene |
| RULE(radius=1) | ([*:1]-[CH;+0:2]=[*:3].[*:4]-[CH;+0:5]=[C;H0;+0:6](-[*:7])-[*:8])>>[*:1]-[C;H0;+0:2](=[*:3])-[C;H0;+0:6](-[*:7])(-[*:8])-[CH2;+0:5]-[*:4] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular analysis of carotenoid cyclase inhibition. | Bouvier F, d'Harlingue A, Camara B | 1997 Oct 1 | 9328284 |
| Characterization of plant carotenoid cyclases as members of the flavoprotein family functioning with no net redox change. | Mialoundama AS, Heintz D, Jadid N, Nkeng P, Rahier A, Deli J, Camara B, Bouvier F | 2010 Jul | 20460582 |
| Cloning and functional expression in Escherichia coli of a cyanobacterial gene for lycopene cyclase, the enzyme that catalyzes the biosynthesis of beta-carotene. | Cunningham FX Jr, Chamovitz D, Misawa N, Gantt E, Hirschberg J | 1993 Aug 9 | 8344419 |
| Identification of a lycopene beta-cyclase required for bacteriorhodopsin biogenesis in the archaeon Halobacterium salinarum. | Peck RF, Johnson EA, Krebs MP | 2002 Jun | 12003928 |
| RHEA:32219 | all-trans-lycopene = gamma-carotene |
| RULE(radius=1) | ([*:1]-[CH;+0:2]=[*:3].[*:4]-[CH;+0:5]=[C;H0;+0:6](-[*:7])-[*:8])>>[*:1]-[C;H0;+0:2](=[*:3])-[C;H0;+0:6](-[*:7])(-[*:8])-[CH2;+0:5]-[*:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular analysis of carotenoid cyclase inhibition. | Bouvier F, d'Harlingue A, Camara B | 1997 Oct 1 | 9328284 |
| Characterization of plant carotenoid cyclases as members of the flavoprotein family functioning with no net redox change. | Mialoundama AS, Heintz D, Jadid N, Nkeng P, Rahier A, Deli J, Camara B, Bouvier F | 2010 Jul | 20460582 |
| Cloning and functional expression in Escherichia coli of a cyanobacterial gene for lycopene cyclase, the enzyme that catalyzes the biosynthesis of beta-carotene. | Cunningham FX Jr, Chamovitz D, Misawa N, Gantt E, Hirschberg J | 1993 Aug 9 | 8344419 |
| Identification of a lycopene beta-cyclase required for bacteriorhodopsin biogenesis in the archaeon Halobacterium salinarum. | Peck RF, Johnson EA, Krebs MP | 2002 Jun | 12003928 |