EC number:5.5.1.2

Enzyme

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     5. Isomerases
        5.5 Intramolecular lyases
            5.5.1 Intramolecular lyases (only sub-subclass identified to date)
ID:5.5.1.2
Description:3-carboxy-cis,cis-muconate cycloisomerase.
Alternative Name: CMLE.
Beta-carboxymuconate lactonizing enzyme.
3-carboxymuconate lactonizing enzyme.
Prosite: PDOC00147;
PDB:
PDBScop
Cath: 1.10.275.10; 1.10.40.30; 1.20.200.10; 1.20.200.30;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 5.5.1.2
BRENDA Enzyme Link: BRENDA 5.5.1.2
KEGG Enzyme Link: KEGG5.5.1.2
BioCyc Enzyme Link: BioCyc 5.5.1.2
ExPASy Enzyme Link: ExPASy5.5.1.2
EC2PDB Enzyme Link: EC2PDB 5.5.1.2
ExplorEnz Enzyme Link: ExplorEnz 5.5.1.2
PRIAM enzyme-specific profiles Link: PRIAM 5.5.1.2
IntEnz Enzyme Link: IntEnz 5.5.1.2
MEDLINE Enzyme Link: MEDLINE 5.5.1.2

EC number:5.5.1.2

MSA:

5.5.1.2;
Phylogenetic Tree:

5.5.1.2;
Uniprot:
M-CSA:
RHEA:23656 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H(+)
RULE(radius=1) [*:1]-[CH2;+0:2]-[C;H0;+0:3](-[*:4])(-[*:5])-[O;H0;+0:6]-[*:7]>>([*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5].[*:7]-[OH;+0:6])
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
The conversion of catechol and protocatechuate to beta-ketoadipate by Pseudomonas putida. II. Enzymes of the protocatechuate pathway.Ornston LN1966 Aug 255916392
Structure and function of the 3-carboxy-cis,cis-muconate lactonizing enzyme from the protocatechuate degradative pathway of Agrobacterium radiobacter S2.Halak S, Lehtiö L, Basta T, Bürger S, Contzen M, Stolz A, Goldman A2006 Nov17054713