EC number:5.5.1.23
Enzyme
Download| EC Tree |
| 5. Isomerases |
| 5.5 Intramolecular lyases |
| 5.5.1 Intramolecular lyases (only sub-subclass identified to date) |
| ID: | 5.5.1.23 |
|---|---|
| Description: | Aklanonic acid methyl ester cyclase. |
| Alternative Name: |
Methyl aklanonate cyclase. |
| Cath: | 3.10.450.50; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 5.5.1.23 |
| BRENDA Enzyme Link: | BRENDA 5.5.1.23 |
| KEGG Enzyme Link: | KEGG5.5.1.23 |
| BioCyc Enzyme Link: | BioCyc 5.5.1.23 |
| ExPASy Enzyme Link: | ExPASy5.5.1.23 |
| EC2PDB Enzyme Link: | EC2PDB 5.5.1.23 |
| ExplorEnz Enzyme Link: | ExplorEnz 5.5.1.23 |
| PRIAM enzyme-specific profiles Link: | PRIAM 5.5.1.23 |
| IntEnz Enzyme Link: | IntEnz 5.5.1.23 |
| MEDLINE Enzyme Link: | MEDLINE 5.5.1.23 |
| RHEA:37879 | methyl aklanonate = aklaviketone |
| RULE(radius=1) | ([*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[CH2;+0:6]-[*:7])>>[*:1]-[C;H0;+0:2](-[*:3])(-[OH;+0:4])-[CH;+0:6](-[*:5])-[*:7] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity. | Kallio P, Sultana A, Niemi J, Mäntsälä P, Schneider G | 2006 Mar 17 | 16414075 |
| DnrD cyclase involved in the biosynthesis of doxorubicin: purification and characterization of the recombinant enzyme. | Kendrew SG, Katayama K, Deutsch E, Madduri K, Hutchinson CR | 1999 Apr 13 | 10200167 |