EC number:5.5.1.27
Enzyme
Download| EC Tree |
| 5. Isomerases |
| 5.5 Intramolecular lyases |
| 5.5.1 Intramolecular lyases (only sub-subclass identified to date) |
| ID: | 5.5.1.27 |
|---|---|
| Description: | D-galactarolactone cycloisomerase. |
| Cath: | 3.20.20.120; 3.30.390.10; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 5.5.1.27 |
| BRENDA Enzyme Link: | BRENDA 5.5.1.27 |
| KEGG Enzyme Link: | KEGG5.5.1.27 |
| BioCyc Enzyme Link: | BioCyc 5.5.1.27 |
| ExPASy Enzyme Link: | ExPASy5.5.1.27 |
| EC2PDB Enzyme Link: | EC2PDB 5.5.1.27 |
| ExplorEnz Enzyme Link: | ExplorEnz 5.5.1.27 |
| PRIAM enzyme-specific profiles Link: | PRIAM 5.5.1.27 |
| IntEnz Enzyme Link: | IntEnz 5.5.1.27 |
| MEDLINE Enzyme Link: | MEDLINE 5.5.1.27 |
| RHEA:45604 | D-glucaro-1,4-lactone = 5-dehydro-4-deoxy-D-glucarate + H(+) |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[O;H0;+0:3]-[*:4])-[CH;+0:5](-[*:6])-[OH;+0:7]>>([*:1]-[CH2;+0:2]-[C;H0;+0:5](-[*:6])=[O;H0;+0:7].[*:4]-[OH;+0:3]) |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Galactaro δ-lactone isomerase: lactone isomerization by a member of the amidohydrolase superfamily. | Bouvier JT, Groninger-Poe FP, Vetting M, Almo SC, Gerlt JA | 2014 Feb 4 | 24450804 |
| Characterization of a novel Agrobacterium tumefaciens galactarolactone cycloisomerase enzyme for direct conversion of D-galactarolactone to 3-deoxy-2-keto-L-threo-hexarate. | Andberg M, Maaheimo H, Boer H, Penttilä M, Koivula A, Richard P | 2012 May 18 | 22493433 |
| RHEA:45600 | D-galactaro-1,4-lactone = 5-dehydro-4-deoxy-D-glucarate + H(+) |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[O;H0;+0:3]-[*:4])-[CH;+0:5](-[*:6])-[OH;+0:7]>>([*:1]-[CH2;+0:2]-[C;H0;+0:5](-[*:6])=[O;H0;+0:7].[*:4]-[OH;+0:3]) |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Galactaro δ-lactone isomerase: lactone isomerization by a member of the amidohydrolase superfamily. | Bouvier JT, Groninger-Poe FP, Vetting M, Almo SC, Gerlt JA | 2014 Feb 4 | 24450804 |
| Characterization of a novel Agrobacterium tumefaciens galactarolactone cycloisomerase enzyme for direct conversion of D-galactarolactone to 3-deoxy-2-keto-L-threo-hexarate. | Andberg M, Maaheimo H, Boer H, Penttilä M, Koivula A, Richard P | 2012 May 18 | 22493433 |
| Purification, crystallization and structural elucidation of D-galactaro-1,4-lactone cycloisomerase from Agrobacterium tumefaciens involved in pectin degradation. | Vetting MW, Bouvier JT, Gerlt JA, Almo SC | 2016 Jan | 26750482 |