EC number:5.5.1.7
Enzyme
Download| EC Tree |
| 5. Isomerases |
| 5.5 Intramolecular lyases |
| 5.5.1 Intramolecular lyases (only sub-subclass identified to date) |
| ID: | 5.5.1.7 | ||
|---|---|---|---|
| Description: | Chloromuconate cycloisomerase. | ||
| Alternative Name: |
Muconate cycloisomerase II. | ||
| Prosite: | PDOC00706; | ||
| PDB: |
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| Cath: | 3.20.20.120; 3.30.390.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 5.5.1.7 |
| BRENDA Enzyme Link: | BRENDA 5.5.1.7 |
| KEGG Enzyme Link: | KEGG5.5.1.7 |
| BioCyc Enzyme Link: | BioCyc 5.5.1.7 |
| ExPASy Enzyme Link: | ExPASy5.5.1.7 |
| EC2PDB Enzyme Link: | EC2PDB 5.5.1.7 |
| ExplorEnz Enzyme Link: | ExplorEnz 5.5.1.7 |
| PRIAM enzyme-specific profiles Link: | PRIAM 5.5.1.7 |
| IntEnz Enzyme Link: | IntEnz 5.5.1.7 |
| MEDLINE Enzyme Link: | MEDLINE 5.5.1.7 |
| RHEA:11032 | (2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[C;H0;+0:3](-[*:4])(-[*:5])-[CH2;+0:6]-[*:7]>>([*:4]-[C;H0;+0:3](-[*:5])=[CH;+0:6]-[*:7].[*:1]-[OH;+0:2]) |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cis,cis-muconate lactonizing enzyme from Trichosporon cutaneum: evidence for a novel class of cycloisomerases in eucaryotes. | Mazur P, Pieken WA, Budihas SR, Williams SE, Wong S, Kozarich JW | 1994 Feb 22 | 8110801 |
| Chemical structure and biodegradability of halogenated aromatic compounds. Conversion of chlorinated muconic acids into maleoylacetic acid. | Schmidt E, Knackmuss HJ | 1980 Oct 15 | 7305906 |
| A re-evaluation of the crystal structure of chloromuconate cycloisomerase. | Kleywegt GJ, Hoier H, Jones TA | 1996 Jul 1 | 15299651 |
| Crystal structure of chloromuconate cycloisomerase from Alcaligenes eutrophus JMP134 (pJP4) at 3 A resolution. | Hoier H, Schlömann M, Hammer A, Glusker JP, Carrell HL, Goldman A, Stezowski JJ, Heinemann U | 1994 Jan 1 | 15299479 |
| The structure of Pseudomonas P51 Cl-muconate lactonizing enzyme: co-evolution of structure and dynamics with the dehalogenation function. | Kajander T, Lehtiö L, Schlömann M, Goldman A | 2003 Sep | 12930985 |
| Mechanism of chloride elimination from 3-chloro- and 2,4-dichloro-cis,cis-muconate: new insight obtained from analysis of muconate cycloisomerase variant CatB-K169A. | Kaulmann U, Kaschabek SR, Schlömann M | 2001 Aug | 11443090 |