EC number:6.1.1.1

Enzyme

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     6. Ligases
        6.1 Forming carbon-oxygen bonds
            6.1.1 Ligases forming aminoacyl-tRNA and related compounds
ID:6.1.1.1
Description:Tyrosine--tRNA ligase.
Alternative Name: Tyrosyl-tRNA synthetase.
Tyrosyl-tRNA ligase.
Tyrosyl-transfer RNA synthetase.
Tyrosyl-transfer ribonucleic acid synthetase.
Tyrosyl-transfer ribonucleate synthetase.
Tyrosine-transfer RNA ligase.
Tyrosine-transfer ribonucleate synthetase.
Tyrosine tRNA synthetase.
Tyrosine translase.
L-tyrosine-tRNA(Tyr) ligase (AMP-forming).
Prosite: PDOC00161;
PDB:
PDBScop
4TS1 8031822; 8044200; 8031822; 8044200;
3TS1 8031822; 8044200;
2TS1 8031822; 8044200;
1TYD 8031822; 8044200;
1TYC 8031822; 8044200;
 » show all
Cath: 1.10.240.10; 3.40.50.620; 2.40.50.140; 3.10.290.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.1.1.1
BRENDA Enzyme Link: BRENDA 6.1.1.1
KEGG Enzyme Link: KEGG6.1.1.1
BioCyc Enzyme Link: BioCyc 6.1.1.1
ExPASy Enzyme Link: ExPASy6.1.1.1
EC2PDB Enzyme Link: EC2PDB 6.1.1.1
ExplorEnz Enzyme Link: ExplorEnz 6.1.1.1
PRIAM enzyme-specific profiles Link: PRIAM 6.1.1.1
IntEnz Enzyme Link: IntEnz 6.1.1.1
MEDLINE Enzyme Link: MEDLINE 6.1.1.1

EC number:6.1.1.1

MSA:

6.1.1.1;
Phylogenetic Tree:

6.1.1.1;
Uniprot:
M-CSA:
RHEA:10220 ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](-[*:4])(=[*:5])-[*:6].[*:7]-[OH;+0:8].[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12]>>[*:7]-[O;H0;+0:8]-[C;H0;+0:10](=[*:9])-[*:11].[*:1]-[OH;+0:2].[*:4]-[P;H0;+0:3](=[*:5])(-[*:6])-[OH;+0:12]
Reaction
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References

TitleAuthorsDatePubMed ID
Demonstration of two tyrosyl-tRNA synthetases of pea roots.Cowles JR, Key JL1972 Sep 294563531
Structure of tyrosyl-tRNA synthetase refined at 2.3 A resolution. Interaction of the enzyme with the tyrosyl adenylate intermediate.Brick P, Bhat TN, Blow DM1989 Jul 52504923
Crystal structure of human mitochondrial tyrosyl-tRNA synthetase reveals common and idiosyncratic features.Bonnefond L, Frugier M, Touzé E, Lorber B, Florentz C, Giegé R, Sauter C, Rudinger-Thirion J2007 Nov17997975
Incorporation of amino acids into ribonucleic acid. I. The role of activating enzymes.ALLEN EH, GLASSMAN E, SCHWEET RS1960 Apr13792726
Partial purification of the threonine- and tyrosine-activating enzymes from rat liver, and the effect of patassium ions on the activity of the tyrosine enzyme.HOLLEY RW, BRUNNGRABER EF, SAAD F, WILLIAMS HH1961 Jan13715350
Purification and properties of tyrosine-activating enzyme of hog pancreas.SCHWEET RS, ALLEN EH1958 Nov13598741
Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS.Bonnefond L, Fender A, Rudinger-Thirion J, Giegé R, Florentz C, Sissler M2005 Mar 2915779907