EC number:6.1.1.27

Enzyme

Download
EC Tree
     6. Ligases
        6.1 Forming carbon-oxygen bonds
            6.1.1 Ligases forming aminoacyl-tRNA and related compounds
ID:6.1.1.27
Description:O-phosphoserine--tRNA ligase.
Alternative Name: SepRS.
O-phosphoseryl-tRNA ligase.
Prosite: PDOC00363;
PDB:
PDBScop
Cath: 1.10.260.120; 3.30.160.480; 3.30.930.10; 3.40.640.10; 3.90.1150.10;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.1.1.27
BRENDA Enzyme Link: BRENDA 6.1.1.27
KEGG Enzyme Link: KEGG6.1.1.27
BioCyc Enzyme Link: BioCyc 6.1.1.27
ExPASy Enzyme Link: ExPASy6.1.1.27
EC2PDB Enzyme Link: EC2PDB 6.1.1.27
ExplorEnz Enzyme Link: ExplorEnz 6.1.1.27
PRIAM enzyme-specific profiles Link: PRIAM 6.1.1.27
IntEnz Enzyme Link: IntEnz 6.1.1.27
MEDLINE Enzyme Link: MEDLINE 6.1.1.27

EC number:6.1.1.27

MSA:

6.1.1.27;
Phylogenetic Tree:

6.1.1.27;
Uniprot:
M-CSA:
RHEA:25678 ATP + O-phospho-L-serine + tRNA(Cys) = AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](-[*:4])(=[*:5])-[*:6].[*:7]-[OH;+0:8].[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12]>>[*:7]-[O;H0;+0:8]-[C;H0;+0:10](=[*:9])-[*:11].[*:1]-[OH;+0:2].[*:4]-[P;H0;+0:3](=[*:5])(-[*:6])-[OH;+0:12]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Redundant synthesis of cysteinyl-tRNACys in Methanosarcina mazei.Hauenstein SI, Perona JJ2008 Aug 818559341
Structural insights into the first step of RNA-dependent cysteine biosynthesis in archaea.Fukunaga R, Yokoyama S2007 Apr17351629