EC number:6.1.2.2
Enzyme
Download| EC Tree |
| 6. Ligases |
| 6.1 Forming carbon-oxygen bonds |
| 6.1.2 acid-alcohol ligases (ester synthases) |
| ID: | 6.1.2.2 |
|---|---|
| Description: | Nebramycin 5' synthase. |
| Alternative Name: |
Tobramycin carbamoyltransferase. |
| Cath: | 3.30.420.350; 3.30.420.40; 3.90.870.20; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 6.1.2.2 |
| BRENDA Enzyme Link: | BRENDA 6.1.2.2 |
| KEGG Enzyme Link: | KEGG6.1.2.2 |
| BioCyc Enzyme Link: | BioCyc 6.1.2.2 |
| ExPASy Enzyme Link: | ExPASy6.1.2.2 |
| EC2PDB Enzyme Link: | EC2PDB 6.1.2.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.1.2.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.1.2.2 |
| IntEnz Enzyme Link: | IntEnz 6.1.2.2 |
| MEDLINE Enzyme Link: | MEDLINE 6.1.2.2 |
| RHEA:42100 | ATP + carbamoyl phosphate + H2O + kanamycin A = 6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]-[P;H0;+0:4](=[*:5])(-[*:6])-[O;H0;+0:7]-[*:8].[*:9]=[C;H0;+0:10](-[*:11])-[O;H0;+0:12]-[*:13].[OH2;+0:14]>>[*:1]-[O;H0;+0:2]-[C;H0;+0:10](=[*:9])-[*:11].[*:8]-[OH;+0:7].[*:13]-[OH;+0:12].[*:3]-[P;H0;+0:4](=[*:5])(-[*:6])-[OH;+0:14] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The O-carbamoyltransferase TobZ catalyzes an ancient enzymatic reaction. | Parthier C, Görlich S, Jaenecke F, Breithaupt C, Bräuer U, Fandrich U, Clausnitzer D, Wehmeier UF, Böttcher C, Scheel D, Stubbs MT | 2012 Apr 23 | 22383337 |
| RHEA:42096 | ATP + carbamoyl phosphate + H2O + tobramycin = AMP + diphosphate + H(+) + nebramycin 5' + phosphate |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]-[P;H0;+0:4](=[*:5])(-[*:6])-[O;H0;+0:7]-[*:8].[*:9]=[C;H0;+0:10](-[*:11])-[O;H0;+0:12]-[*:13].[OH2;+0:14]>>[*:1]-[O;H0;+0:2]-[C;H0;+0:10](=[*:9])-[*:11].[*:8]-[OH;+0:7].[*:13]-[OH;+0:12].[*:3]-[P;H0;+0:4](=[*:5])(-[*:6])-[OH;+0:14] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The O-carbamoyltransferase TobZ catalyzes an ancient enzymatic reaction. | Parthier C, Görlich S, Jaenecke F, Breithaupt C, Bräuer U, Fandrich U, Clausnitzer D, Wehmeier UF, Böttcher C, Scheel D, Stubbs MT | 2012 Apr 23 | 22383337 |