EC number:6.2.1.12

Enzyme

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EC Tree
     6. Ligases
        6.2 Forming carbon-sulfur bonds
            6.2.1 Acid-thiol ligases
ID:6.2.1.12
Description:4-coumarate--CoA ligase.
Alternative Name: 4-coumaryl-CoA synthetase.
4-coumaroyl-CoA synthase.
Prosite: PDOC00427;
PDB:
PDBScop
Cath: 3.30.300.30; 3.40.47.10; 3.40.50.12780;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.2.1.12
BRENDA Enzyme Link: BRENDA 6.2.1.12
KEGG Enzyme Link: KEGG6.2.1.12
BioCyc Enzyme Link: BioCyc 6.2.1.12
ExPASy Enzyme Link: ExPASy6.2.1.12
EC2PDB Enzyme Link: EC2PDB 6.2.1.12
ExplorEnz Enzyme Link: ExplorEnz 6.2.1.12
PRIAM enzyme-specific profiles Link: PRIAM 6.2.1.12
IntEnz Enzyme Link: IntEnz 6.2.1.12
MEDLINE Enzyme Link: MEDLINE 6.2.1.12

EC number:6.2.1.12

MSA:

6.2.1.12;
Phylogenetic Tree:

6.2.1.12;
Uniprot:
M-CSA:
RHEA:19641 4-coumarate + ATP + CoA = 4-coumaroyl-CoA + AMP + diphosphate
RULE(radius=1) [*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[*:7]-[SH;+0:8].[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[OH;+0:12].[*:7]-[S;H0;+0:8]-[C;H0;+0:10](=[*:9])-[*:11]
Reaction
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References

TitleAuthorsDatePubMed ID
Structural and kinetic analysis of the unnatural fusion protein 4-coumaroyl-CoA ligase::stilbene synthase.Wang Y, Yi H, Wang M, Yu O, Jez JM2011 Dec 2822129213