EC number:6.2.1.13

Enzyme

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     6. Ligases
        6.2 Forming carbon-sulfur bonds
            6.2.1 Acid-thiol ligases
ID:6.2.1.13
Description:Acetate--CoA ligase (ADP-forming).
Alternative Name: Acetyl-CoA synthetase (ADP-forming).
Acetate thiokinase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.2.1.13
BRENDA Enzyme Link: BRENDA 6.2.1.13
KEGG Enzyme Link: KEGG6.2.1.13
BioCyc Enzyme Link: BioCyc 6.2.1.13
ExPASy Enzyme Link: ExPASy6.2.1.13
EC2PDB Enzyme Link: EC2PDB 6.2.1.13
ExplorEnz Enzyme Link: ExplorEnz 6.2.1.13
PRIAM enzyme-specific profiles Link: PRIAM 6.2.1.13
IntEnz Enzyme Link: IntEnz 6.2.1.13
MEDLINE Enzyme Link: MEDLINE 6.2.1.13

EC number:6.2.1.13

MSA:

6.2.1.13;
Phylogenetic Tree:

6.2.1.13;
Uniprot:
M-CSA:
RHEA:29843 ATP + CoA + propanoate = ADP + phosphate + propanoyl-CoA
RULE(radius=1) [*:1]-[SH;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:12]-[OH;+0:11].[*:1]-[S;H0;+0:2]-[C;H0;+0:4](=[*:3])-[*:5].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction
RHEA:15081 acetate + ATP + CoA = acetyl-CoA + ADP + phosphate
RULE(radius=1) [*:1]-[SH;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:12]-[OH;+0:11].[*:1]-[S;H0;+0:2]-[C;H0;+0:4](=[*:3])-[*:5].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
An energy-conserving pyruvate-to-acetate pathway in Entamoeba histolytica. Pyruvate synthase and a new acetate thiokinase.Reeves RE, Warren LG, Susskind B, Lo HS1977 Jan 2513076