EC number:6.2.1.14
| ID: | 6.2.1.14 |
|---|---|
| Description: | 6-carboxyhexanoate--CoA ligase. |
| Alternative Name: |
Pimeloyl-CoA synthetase. 6-carboxyhexanoyl-CoA synthetase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.2.1.14 |
| BRENDA Enzyme Link: | BRENDA 6.2.1.14 |
| KEGG Enzyme Link: | KEGG6.2.1.14 |
| BioCyc Enzyme Link: | BioCyc 6.2.1.14 |
| ExPASy Enzyme Link: | ExPASy6.2.1.14 |
| EC2PDB Enzyme Link: | EC2PDB 6.2.1.14 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.2.1.14 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.2.1.14 |
| IntEnz Enzyme Link: | IntEnz 6.2.1.14 |
| MEDLINE Enzyme Link: | MEDLINE 6.2.1.14 |
| RHEA:14781 | ATP + CoA + heptanedioate = AMP + diphosphate + heptanedioyl-CoA |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:4].[*:5]-[P;H0;+0:6](=[*:7])(-[*:8])-[O;H0;+0:9]-[*:10].[*:11]-[SH;+0:12]>>[*:10]-[OH;+0:9].[*:5]-[P;H0;+0:6](=[*:7])(-[*:8])-[OH;+0:4].[*:11]-[S;H0;+0:12]-[C;H0;+0:2](-[*:1])=[*:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Investigation of the first step of biotin biosynthesis in Bacillus sphaericus. Purification and characterization of the pimeloyl-CoA synthase, and uptake of pimelate. | Ploux O, Soularue P, Marquet A, Gloeckler R, Lemoine Y | 1992 Nov 1 | 1445232 |
| Using the pimeloyl-CoA synthetase adenylation fold to synthesize fatty acid thioesters. | Wang M, Moynié L, Harrison PJ, Kelly V, Piper A, Naismith JH, Campopiano DJ | 2017 Jun | 28414710 |