EC number:6.2.1.15
| ID: | 6.2.1.15 |
|---|---|
| Description: | Arachidonate--CoA ligase. |
| Alternative Name: |
Arachidonoyl-CoA synthetase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.2.1.15 |
| BRENDA Enzyme Link: | BRENDA 6.2.1.15 |
| KEGG Enzyme Link: | KEGG6.2.1.15 |
| BioCyc Enzyme Link: | BioCyc 6.2.1.15 |
| ExPASy Enzyme Link: | ExPASy6.2.1.15 |
| EC2PDB Enzyme Link: | EC2PDB 6.2.1.15 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.2.1.15 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.2.1.15 |
| IntEnz Enzyme Link: | IntEnz 6.2.1.15 |
| MEDLINE Enzyme Link: | MEDLINE 6.2.1.15 |
| RHEA:19713 | (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate |
| RULE(radius=1) | [*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[*:7]-[SH;+0:8].[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[OH;+0:12].[*:7]-[S;H0;+0:8]-[C;H0;+0:10](=[*:9])-[*:11] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Discovery of an arachidonoyl coenzyme A synthetase in human platelets. | Wilson DB, Prescott SM, Majerus PW | 1982 Apr 10 | 7061494 |
| Long-chain acyl-CoA synthetase isoforms differ in preferences for eicosanoid species and long-chain fatty acids. | Klett EL, Chen S, Yechoor A, Lih FB, Coleman RA | 2017 May | 28209804 |
| Very long-chain acyl-CoA synthetase 3: overexpression and growth dependence in lung cancer. | Pei Z, Fraisl P, Shi X, Gabrielson E, Forss-Petter S, Berger J, Watkins PA | 2013 | 23936004 |
| Long-chain acyl-CoA synthetase 4 modulates prostaglandin E₂ release from human arterial smooth muscle cells. | Golej DL, Askari B, Kramer F, Barnhart S, Vivekanandan-Giri A, Pennathur S, Bornfeldt KE | 2011 Apr | 21242590 |
| Functional domains of the fatty acid transport proteins: studies using protein chimeras. | DiRusso CC, Darwis D, Obermeyer T, Black PN | 2008 Mar | 18258213 |
| A novel mammalian bubblegum-related acyl-CoA synthetase restricted to testes and possibly involved in spermatogenesis. | Fraisl P, Tanaka H, Forss-Petter S, Lassmann H, Nishimune Y, Berger J | 2006 Jul 1 | 16762313 |
| Comparative biochemical studies of the murine fatty acid transport proteins (FATP) expressed in yeast. | DiRusso CC, Li H, Darwis D, Watkins PA, Berger J, Black PN | 2005 Apr 29 | 15699031 |