Enzyme

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EC Tree
     6. Ligases
        6.2 Forming carbon-sulfur bonds
            6.2.1 Acid-thiol ligases
ID:6.2.1.25
Description:Benzoate--CoA ligase.
Cath: 1.10.10.2900; 3.30.300.30; 3.40.50.980; 2.30.38.10; 3.40.50.12780;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 6.2.1.25
BRENDA Enzyme Link: BRENDA 6.2.1.25
KEGG Enzyme Link: KEGG6.2.1.25
BioCyc Enzyme Link: BioCyc 6.2.1.25
ExPASy Enzyme Link: ExPASy6.2.1.25
EC2PDB Enzyme Link: EC2PDB 6.2.1.25
ExplorEnz Enzyme Link: ExplorEnz 6.2.1.25
PRIAM enzyme-specific profiles Link: PRIAM 6.2.1.25
IntEnz Enzyme Link: IntEnz 6.2.1.25
MEDLINE Enzyme Link: MEDLINE 6.2.1.25
MSA:

6.2.1.25;

Phylogenetic Tree:

6.2.1.25;

Uniprot:
M-CSA:
RHEA:10132 ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate
RULE(radius=1) [*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[*:7]-[SH;+0:8].[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[OH;+0:12].[*:7]-[S;H0;+0:8]-[C;H0;+0:10](=[*:9])-[*:11]
Reaction
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References

TitleAuthorsDatePubMed ID
4-Hydroxybenzoate-coenzyme A ligase from Rhodopseudomonas palustris: purification, gene sequence, and role in anaerobic degradation.Gibson J, Dispensa M, Fogg GC, Evans DT, Harwood CS1994 Feb8300518
Characterization of seed-specific benzoyloxyglucosinolate mutations in Arabidopsis thaliana.Kliebenstein DJ, D'Auria JC, Behere AS, Kim JH, Gunderson KL, Breen JN, Lee G, Gershenzon J, Last RL, Jander G2007 Sep17651367
Benzoate-coenzyme A ligase from Thauera aromatica: an enzyme acting in anaerobic and aerobic pathways.Schühle K, Gescher J, Feil U, Paul M, Jahn M, Schägger H, Fuchs G2003 Aug12897012
O-MACS, a novel member of the medium-chain acyl-CoA synthetase family, specifically expressed in the olfactory epithelium in a zone-specific manner.Oka Y, Kobayakawa K, Nishizumi H, Miyamichi K, Hirose S, Tsuboi A, Sakano H2003 May12709059
Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria.Vessey DA, Lau E, Kelley M, Warren RS200312616642
Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids.Vessey DA, Kelley M, Warren RS1999 Aug 510434065