EC number:6.2.1.26

Enzyme

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EC Tree
     6. Ligases
        6.2 Forming carbon-sulfur bonds
            6.2.1 Acid-thiol ligases
ID:6.2.1.26
Description:o-succinylbenzoate--CoA ligase.
Alternative Name: OSB-CoA synthetase.
o-succinylbenzoyl-CoA synthetase.
Prosite: PDOC00427;
PDB:
PDBScop
Cath: 3.30.300.30; 3.40.50.12780;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.2.1.26
BRENDA Enzyme Link: BRENDA 6.2.1.26
KEGG Enzyme Link: KEGG6.2.1.26
BioCyc Enzyme Link: BioCyc 6.2.1.26
ExPASy Enzyme Link: ExPASy6.2.1.26
EC2PDB Enzyme Link: EC2PDB 6.2.1.26
ExplorEnz Enzyme Link: ExplorEnz 6.2.1.26
PRIAM enzyme-specific profiles Link: PRIAM 6.2.1.26
IntEnz Enzyme Link: IntEnz 6.2.1.26
MEDLINE Enzyme Link: MEDLINE 6.2.1.26

EC number:6.2.1.26

MSA:

6.2.1.26;
Phylogenetic Tree:

6.2.1.26;
Uniprot:
M-CSA:
RHEA:17009 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate
RULE(radius=1) [*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:4].[*:5]-[P;H0;+0:6](=[*:7])(-[*:8])-[O;H0;+0:9]-[*:10].[*:11]-[SH;+0:12]>>[*:10]-[OH;+0:9].[*:5]-[P;H0;+0:6](=[*:7])(-[*:8])-[OH;+0:4].[*:11]-[S;H0;+0:12]-[C;H0;+0:2](-[*:1])=[*:3]
Reaction
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References

TitleAuthorsDatePubMed ID
Enzymatic synthesis, characterization, and metabolism of the coenzyme A ester of o-succinylbenzoic acid, an intermediate in menaquinone (vitamin K2) biosynthesis.Heide L, Arendt S, Leistner E1982 Jul 107045104
Menaquinone (vitamin K2) biosynthesis: conversion of o-succinylbenzoic acid to 1,4-dihydroxy-2-naphthoic acid by Mycobacterium phlei enzymes.Meganathan R, Bentley R1979 Oct500558
4-(2'-Carboxyphenyl)-4-oxobutyryl coenzyme A ester, an intermediate in vitamin K2 (menaquinone) biosynthesis.Kolkmann R, Leistner E1987 Nov-Dec2966501