EC number:6.2.1.39

Enzyme

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     6. Ligases
        6.2 Forming carbon-sulfur bonds
            6.2.1 Acid-thiol ligases
ID:6.2.1.39
Description:[Butirosin acyl-carrier protein]--L-glutamate ligase.
Alternative Name: [BtrI acyl-carrier protein]--L-glutamate ligase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.2.1.39
BRENDA Enzyme Link: BRENDA 6.2.1.39
KEGG Enzyme Link: KEGG6.2.1.39
BioCyc Enzyme Link: BioCyc 6.2.1.39
ExPASy Enzyme Link: ExPASy6.2.1.39
EC2PDB Enzyme Link: EC2PDB 6.2.1.39
ExplorEnz Enzyme Link: ExplorEnz 6.2.1.39
PRIAM enzyme-specific profiles Link: PRIAM 6.2.1.39
IntEnz Enzyme Link: IntEnz 6.2.1.39
MEDLINE Enzyme Link: MEDLINE 6.2.1.39

EC number:6.2.1.39

MSA:

6.2.1.39;
Phylogenetic Tree:

6.2.1.39;
Uniprot:
M-CSA:
RHEA:53952 4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate = 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:1]-[NH;+0:2]-[C;H0;+0:4](=[*:3])-[*:5].[*:12]-[OH;+0:11].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway.Li Y, Llewellyn NM, Giri R, Huang F, Spencer JB2005 Jun15975512
Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain.Llewellyn NM, Li Y, Spencer JB2007 Apr17462573
RHEA:53948 ATP + holo-[BtrI ACP] + L-glutamate = ADP + L-glutamyl-[BtrI ACP] + phosphate
RULE(radius=1) [*:1]-[SH;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[OH;+0:6].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[O;H0;+0:11]-[*:12]>>[*:12]-[OH;+0:11].[*:1]-[S;H0;+0:2]-[C;H0;+0:4](=[*:3])-[*:5].[*:7]=[P;H0;+0:8](-[*:9])(-[*:10])-[OH;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway.Li Y, Llewellyn NM, Giri R, Huang F, Spencer JB2005 Jun15975512
Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain.Llewellyn NM, Li Y, Spencer JB2007 Apr17462573