EC number:6.2.1.4

Enzyme

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EC Tree
     6. Ligases
        6.2 Forming carbon-sulfur bonds
            6.2.1 Acid-thiol ligases
ID:6.2.1.4
Description:Succinate--CoA ligase (GDP-forming).
Alternative Name: Succinyl-CoA synthetase (GDP-forming).
Prosite: PDOC00335;
PDB:
PDBScop
Cath: 3.30.1490.20; 3.30.470.20; 3.40.50.720; 3.40.50.261;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.2.1.4
BRENDA Enzyme Link: BRENDA 6.2.1.4
KEGG Enzyme Link: KEGG6.2.1.4
BioCyc Enzyme Link: BioCyc 6.2.1.4
ExPASy Enzyme Link: ExPASy6.2.1.4
EC2PDB Enzyme Link: EC2PDB 6.2.1.4
ExplorEnz Enzyme Link: ExplorEnz 6.2.1.4
PRIAM enzyme-specific profiles Link: PRIAM 6.2.1.4
IntEnz Enzyme Link: IntEnz 6.2.1.4
MEDLINE Enzyme Link: MEDLINE 6.2.1.4

EC number:6.2.1.4

MSA:

6.2.1.4;
Phylogenetic Tree:

6.2.1.4;
Uniprot:
M-CSA:
RHEA:22120 CoA + GTP + succinate = GDP + phosphate + succinyl-CoA
RULE(radius=1) [*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:4].[*:5]-[O;H0;+0:6]-[P;H0;+0:7](=[*:8])(-[*:9])-[*:10].[*:11]-[SH;+0:12]>>[*:5]-[OH;+0:6].[*:11]-[S;H0;+0:12]-[C;H0;+0:2](-[*:1])=[*:3].[*:8]=[P;H0;+0:7](-[*:9])(-[*:10])-[OH;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Identification of the kinetic mechanism of succinyl-CoA synthetase.Li X, Wu F, Beard DA2013 Jan 1823088689