EC number:6.2.1.43

Enzyme

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EC Tree
     6. Ligases
        6.2 Forming carbon-sulfur bonds
            6.2.1 Acid-thiol ligases
ID:6.2.1.43
Description:2-hydroxy-7-methoxy-5-methyl-1-naphthoate--CoA ligase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 6.2.1.43
BRENDA Enzyme Link: BRENDA 6.2.1.43
KEGG Enzyme Link: KEGG6.2.1.43
BioCyc Enzyme Link: BioCyc 6.2.1.43
ExPASy Enzyme Link: ExPASy6.2.1.43
EC2PDB Enzyme Link: EC2PDB 6.2.1.43
ExplorEnz Enzyme Link: ExplorEnz 6.2.1.43
PRIAM enzyme-specific profiles Link: PRIAM 6.2.1.43
IntEnz Enzyme Link: IntEnz 6.2.1.43
MEDLINE Enzyme Link: MEDLINE 6.2.1.43

EC number:6.2.1.43

MSA:

6.2.1.43;
Phylogenetic Tree:

6.2.1.43;
Uniprot:
M-CSA:
RHEA:41644 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA = 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate
RULE(radius=1) [*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[*:7]-[SH;+0:8].[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[OH;+0:12].[*:7]-[S;H0;+0:8]-[C;H0;+0:10](=[*:9])-[*:11]
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References

TitleAuthorsDatePubMed ID
Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.Cooke HA, Zhang J, Griffin MA, Nonaka K, Van Lanen SG, Shen B, Bruner SD2007 Jun 2717539640