EC number:6.2.1.48
| ID: | 6.2.1.48 |
|---|---|
| Description: | Carnitine--CoA ligase. |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 6.2.1.48 |
| BRENDA Enzyme Link: | BRENDA 6.2.1.48 |
| KEGG Enzyme Link: | KEGG6.2.1.48 |
| BioCyc Enzyme Link: | BioCyc 6.2.1.48 |
| ExPASy Enzyme Link: | ExPASy6.2.1.48 |
| EC2PDB Enzyme Link: | EC2PDB 6.2.1.48 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.2.1.48 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.2.1.48 |
| IntEnz Enzyme Link: | IntEnz 6.2.1.48 |
| MEDLINE Enzyme Link: | MEDLINE 6.2.1.48 |
| RHEA:55960 | 4-(trimethylamino)butanoate + ATP + CoA = AMP + diphosphate + gamma-butyrobetainyl-CoA |
| RULE(radius=1) | [*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[*:7]-[SH;+0:8].[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[OH;+0:12].[*:7]-[S;H0;+0:8]-[C;H0;+0:10](=[*:9])-[*:11] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Role of betaine:CoA ligase (CaiC) in the activation of betaines and the transfer of coenzyme A in Escherichia coli. | Bernal V, Arense P, Blatz V, Mandrand-Berthelot MA, Cánovas M, Iborra JL | 2008 Jul | 18266698 |
| RHEA:30079 | ATP + CoA + crotonobetaine = AMP + crotonobetainyl-CoA + diphosphate |
| RULE(radius=1) | [*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[*:7]-[SH;+0:8].[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[OH;+0:12].[*:7]-[S;H0;+0:8]-[C;H0;+0:10](=[*:9])-[*:11] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Role of betaine:CoA ligase (CaiC) in the activation of betaines and the transfer of coenzyme A in Escherichia coli. | Bernal V, Arense P, Blatz V, Mandrand-Berthelot MA, Cánovas M, Iborra JL | 2008 Jul | 18266698 |
| RHEA:28514 | (R)-carnitine + ATP + CoA = (R)-carnitinyl-CoA + AMP + diphosphate |
| RULE(radius=1) | [*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[*:7]-[SH;+0:8].[*:9]=[C;H0;+0:10](-[*:11])-[OH;+0:12]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[OH;+0:12].[*:7]-[S;H0;+0:8]-[C;H0;+0:10](=[*:9])-[*:11] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular characterization of the cai operon necessary for carnitine metabolism in Escherichia coli. | Eichler K, Bourgis F, Buchet A, Kleber HP, Mandrand-Berthelot MA | 1994 Sep | 7815937 |
| Role of betaine:CoA ligase (CaiC) in the activation of betaines and the transfer of coenzyme A in Escherichia coli. | Bernal V, Arense P, Blatz V, Mandrand-Berthelot MA, Cánovas M, Iborra JL | 2008 Jul | 18266698 |