EC number:6.2.1.49
| ID: | 6.2.1.49 |
|---|---|
| Description: | Long-chain fatty acid adenylyltransferase FadD28. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 6.2.1.49 |
| BRENDA Enzyme Link: | BRENDA 6.2.1.49 |
| KEGG Enzyme Link: | KEGG6.2.1.49 |
| BioCyc Enzyme Link: | BioCyc 6.2.1.49 |
| ExPASy Enzyme Link: | ExPASy6.2.1.49 |
| EC2PDB Enzyme Link: | EC2PDB 6.2.1.49 |
| ExplorEnz Enzyme Link: | ExplorEnz 6.2.1.49 |
| PRIAM enzyme-specific profiles Link: | PRIAM 6.2.1.49 |
| IntEnz Enzyme Link: | IntEnz 6.2.1.49 |
| MEDLINE Enzyme Link: | MEDLINE 6.2.1.49 |
| RHEA:10696 | a holo-[mycocerosate synthase] + a long-chain fatty acid + ATP = a long-chain acyl-[mycocerosate synthase] + AMP + diphosphate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:4].[*:5]-[O;H0;+0:6]-[P;H0;+0:7](-[*:8])(=[*:9])-[*:10].[*:11]-[SH;+0:12]>>[*:5]-[OH;+0:6].[*:8]-[P;H0;+0:7](=[*:9])(-[*:10])-[OH;+0:4].[*:11]-[S;H0;+0:12]-[C;H0;+0:2](-[*:1])=[*:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Open reading frame 3, which is adjacent to the mycocerosic acid synthase gene, is expressed as an acyl coenzyme A synthase in Mycobacterium bovis BCG. | Fitzmaurice AM, Kolattukudy PE | 1997 Apr | 9098059 |
| Biosynthesis of cell envelope-associated phenolic glycolipids in Mycobacterium marinum. | Vergnolle O, Chavadi SS, Edupuganti UR, Mohandas P, Chan C, Zeng J, Kopylov M, Angelo NG, Warren JD, Soll CE, Quadri LE | 2015 Mar | 25561717 |
| Expanding the chemical diversity of natural esters by engineering a polyketide-derived pathway into Escherichia coli. | Menendez-Bravo S, Comba S, Sabatini M, Arabolaza A, Gramajo H | 2014 Jul | 24831705 |
| Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis. | Arora P, Goyal A, Natarajan VT, Rajakumara E, Verma P, Gupta R, Yousuf M, Trivedi OA, Mohanty D, Tyagi A, Sankaranarayanan R, Gokhale RS | 2009 Mar | 19182784 |
| Crystallization and preliminary X-ray crystallographic studies of the N-terminal domain of FadD28, a fatty-acyl AMP ligase from Mycobacterium tuberculosis. | Goyal A, Yousuf M, Rajakumara E, Arora P, Gokhale RS, Sankaranarayanan R | 2006 Apr 1 | 16582482 |